In Vitro Sensitivity of Bacteria to Sulfonamide Combinations as Compared to Single Sulfonamides. ∗

Conclusion

The use of sulfonamide mixtures in preference to a single effective sulfonamidle is justified only when in vitro sensitivity tests demonstrate for the components of the mixture either an additive or a potentiating effect. Such tests suggest that this is likely to be true in the majority of coccal infections, but not for gram-negative bacillary infections.