Experimental Studies on Pathogenesis of Hemoglobinuric Nephrosis

Summary and Conclusions

Prolonged hemorrhagic shock was produced in 13 dogs. This was followed by infusions of hemolysed blood with or without red blood cell stroma. The animals were then brought out of shock with transfusions of their own blood. Four dogs died within 17 hours of anesthetic complications or ‘irreversible’ shock. The 9 surviving dogs revealed no evidence of hemoglobinuric nephrosis, and were completely well within 20 hours. In this study the combination of prolonged hemorrhagic shock and hemoglobinuria failed to produce hemoglobinuric nephrosis.