Effect of Hypophysectomy on Electrolyte and Water Metabolism in the Dog. ∗ †

Summary

Study of hypophysectomized dogs that manifest (a) atrophic changes in all three cortical layers of the adrenals, (b) severe disturbances in carbohydrate and protein metabolism and (c) reduced renal functions (glomerular filtration rate, renal plasma flow and tubular transfer maxima) reveals that: (1) their ability to excrete an orally administered water load is impaired, (2) their ability to withstand sodium restriction is normal and (3) their renal tubules retain the ability to excrete potassium and the animals are able to handle potassium loads almost as well as the normals.