Failure of Transfusion of Hemophilic Plasma to Induce Abnormalities of Hemostatic Mechanism in Normal Individuals

Summary

In an attempt to demonstrate the presence of a circulating anticoagulant in hemophilia, normal human subjects were transfused with compatible hemophilic plasma. No effect on the hemostatic mechanism of normal subjects was demonstrated following the transfusion, nor did the ability of the recipient's plasma to correct the clotting defect of known hemophilic plasma change following this procedure.