Abstract
Summary
1. SK 3818, N,N′,N′-triethylene-phosphoramide and SK 4614, N,N-diethyl-N′, N′-diethylenephosphoramide are both capable of retarding the growth of Sarcoma 180 in mice 24 hours and four days after implantation of tumor. Among the chemotherapeutic agents tested in our laboratory SK 3818 has shown the greatest effective dose range. 2. Histopathological examination of tumors of mice treated with SK 3818 and SK 4614 showed enlargement of cells with vacuolar degeneration of cytoplasm, enlargement of nuclei and nucleoli. Furthermore, the number of mitoses was decreased. Numerous cells showed nuclear alterations as commonly encountered during necrosis such as pyknosis, karyolysis and karyorrhexis. 3. Histopathological examination of organs of mice treated with SK 3818 and SK. 4614 revealed lesions similar to the ones occurring during administration of nitrogen mustards: intestinal damage and depletion of myeloid and lymphoid system with leucopenia (granulocytopenia and relative increase of mononuclear cells) in the peripheral blood.
Get full access to this article
View all access options for this article.