Abstract
Summary
Specific complement-fixing antigens were prepared from cotton rat tissues infected with Lansing poliomyelitis, rabies, and St. Louis encephalitis viruses. The antigens were prepared by concentration of the viruses through high speed centrifugation. Lansing antigens prepared from lyophilized tissues were of little value as CF antigens.
A relatively rapid rise and fall in poliomyelitis complement-fixing antibody levels in cotton rats is described. The Lansing antigen fixed complement with serum from Lansing-immune monkeys, but not with serum frommonkeys similarly immunized against Brun-hilde and Leon viruses.
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