Resistance Induced by Alien Strain Mouse Lymphoid Tissue to Lymphosarcoma 6-C3H-ED in C3H Mice

Summary

Lymph node and thymus mixtures, or spleen tissue from certain strains of mice implanted in JAX-C3H mice, 4-7 days prior to subcutaneous injection of lymphosarcoma cells, protect some of the mice so treated against progressive growth of the tumor. - This protection is manifest either by failure of the tumor to grow at the site of implantation or by regression of palpable tumors. Such protected mice are immune to subsequent reimplantation of the tumor. Mice implanted 2-4 days after, or on the day of tumor implantation are not protected. Embryo skin, mammary tissue, leg or heart muscle, from mice whose lymphoid tissue is active failed to protect. Under the conditions of the experiments tissue from some strains of mice were more powerful in eliciting protection than those of other strains.