Abstract
Summary
Adenine, adenosine, cytidine, guanosine and thymine inhibit the propagation of Theiler's GDVII strain of murine encephalomyelitis virus in tissue cultures of one-day mouse brain. Guanine, uridine, uracil, guanylic or cytidylic acids did not inhibit. Various substituted nucleosides including amino-, chloro-, diazo-, formamido-, hydroxy- and methyluridine were inhibitory. Uridine partially reversed this inhibition. 5-Chlorouracil, ribosylthymine and glucosylthymine did not inhibit; 2,6-diaminopurine did. 5-Chlorouridine was not effective against this viral infection in mice.
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