Influence of Hemagglutinating Viruses on Tumor Cell Suspensions: I. Growth Inhibition and Reversal of the Effect. ∗

Summary

1. When mixtures of sarcoma 180 and active NDV allantoic fluid are mixed at 4°C and inoculated subcutaneously into mice an inhibition of tumor growth takes place. This is associated with a fall in hemagglutination titer. After the mixtures have been brought to room temperature for one to 3 hours subcutaneous inoculation results in tumor growth. This is usually associated with an increase in hemagglutination titer. 2. No evidence has been found for the multiplication of the virus in the sarcoma 180. The results are discussed as an analogy with the hemagglutination of red blood cells by the Influenza-Mumps-NDV group of viruses.