Linkage Studies of Genes for Sickling and MNS Blood Groups

Summary

Analysis of data supplied by 55 Negro families comprising 325 kindred, failed to reveal linkage between the MNS blood group genes and the gene for sickling. These findings are not in accord with those of Snyder and coworkers. Thus an example of autosomal linkage, for which Snyder et al. presented evidence, is now in doubt and warrants further investigation. Data ascertainable for linkage calculations between the blood group S and sickling, and MN and S were very small. Linkage between S and sickling could not be found. The blood groups MN and S afforded evidence for linkage thus fitting into the very considerable evidence on this point for Caucasians.