Effects of the Hyperglycemic-Glycogenolytic Factor (HGF),Epinephrine and Insulin in Normal and Depancreatized Dogs. ∗

Conclusions

1. The hyperglycemia produced by HGF and by epinephrine in the depancr-eatized dog with ketosis is greater in animals with mild ketosis than in animals with severe ketosis. 2. Since ketosis is believed to increase as liver glycogen decreases these results suggest that the hyperglycemic response to HGF and epinephrine depends upon the amount of liver glycogen present. 3. In the well controlled depancreatized dog without ketosis, on the other hand, the hyperglycemic effect of HGF is greater than in the normal animal, suggesting that in the presence of the pancreas, the action of HGF is limited by the secretion of insulin. 4. Similarly, in the well controlled depancreatized dog without ketosis, the hypoglycemic effect ofinsulin is greater than in the normal animal, suggesting that in the presence of the pancreas the action of insulin is limited by the secretion of HGF. 5. It is suggested that HGF and insulin might be 2 mutually regulated pancreatic hormones and that their balanced secretion might be an important factor in the maintenance of a normal blood sugar concentration.