Abstract
Summary
The influence of nitrogen mustards on citrate synthesis in rat tissues in vivo was studied using the fluoroacetate technic of Potter(2). The results of this study demonstrated that HN1 and HN2 produce alterations in citrate synthesis in certain tissues which are qualitatively similar to those produced by X-ray. Thus, a decrease in citrate synthesis was observed in spleen and thymus glands of nitrogen mustard-poisoned animals and a marked increase in citrate accumulation was observed in the livers of male rats. The increase in citrate accumulation in the liver was evident after doses far below the LD50 and persisted for several weeks following sublethal doses of the nitrogen mustards.
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