Abstract
Summary
Administration of nephrotoxic globulin (NTG) to the rat produces death in less than 12 hours if the amount given is sufficient. Bilateral nephrectomy usually does not lead to death in less than 24 hours, when the animals are maintained on a stock diet containing 17% protein. The prompt death is related principally to anti-rat-tissue antibodies other than anti-rat-kidney. Anti-rat-erythrocyte is of definite but minor significance in the production of prompt death. Cortisone and tripelennamine exert no protection against the prompt death described. It is evident that nephrotoxic globulin (NTG) has important extrarenal effects which must be considered in comparing NTG nephritis with other similar diseases of the kidney, such as those of natural occurrence in man.
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