Comparison of Eosinophil and Circulating 17-Hydroxycorticosteroid Responses to Epinephrine and ACTH. ∗

Summary

1. A comparison of the responses of eosinophils and of circulating 17-hydroxycorticosteroid plasma concentrations; is presented. 2. In general, responses of eosinophils and 17-hydroxycorticosteroids to the injection of ACTH are adequate, with a reduction of the former and an elevation of the latter. 3. Certain exceptions to this generalization are noted. On the basis of these exceptions the question is raised whether the eosinopenic response to ACTH need be mediated by the mechanism previously accepted. 4. There is a strong suggestion that the eosinopenia in response to epinephrine is not mediated by an increased circulating concentration of 17-hydroxycorticosteroids secreted by the adrenal cortex.