Abstract
Summary
By immunizing rabbits with a lipoprotein fraction obtained from the serum of a dog on a cholesterol-thiouracil atherogenic diet, it has been possible to produce immune sera which will detect the abnormally increased concentration of serum lipoproteins in dogs on cholesterol-thiouracil atherogenic diets and which will react with the serum from an atherosclerotic man. Sera of normal dogs tested with this immune serum by the precipitin technic, consistently show a lipoprotein concentration significantly less than that observed in the case of dogs on the atherogenic dietary regimen. Sera from three men in whom no vascular disease had been detected, did not react with the immune rabbit sera.
Get full access to this article
View all access options for this article.