Effects of Dimenhydrinate and Diphenhydramine on Apomorphine-Induced Emesis in Dogs and Cats. ∗

Summary

1. Neither Dramamine (2, 5 and 10 mg/kg) nor Benadryl (1 and 2.5 mg/kg) administered intravenously was effective in preventing the emetic responses to threshold doses of intravenous apomorphine or in prolonging the latent periods of vomiting in 5 standardized dogs. 2. Other experiments were performed in the attempt to verify the reported protection afforded by Dramamine and Benadryl against apomorphine-induced emesis in dogs and cats. Although the latent period of emesis was prolonged in one of the experiments on cats, these drugs did not prevent vomiting.