Effect of Soybean Phosphatide on Blood Coagulation Defect Following Total Body X-Irradiation in the Dog. ∗

Summary

Thrombocytopenia, prolonged whole blood clotting time, and markedly impaired clot retraction and prothrombin utilization were induced in dogs by 150 r total body x-irradiation. A marked increase in prothrombin utilization was found after the addition of a soybean phosphatide solution to the blood in vitro. A temporary decrease in the clotting time and an increase in prothrombin utilization, without change in the platelet count or clot retraction, was induced by the intravenous administration of 20 to 100 ml of a 2.5% solution of the soybean phosphatide.