Chemoprophylaxis and Chemotherapy of Experimental Poliomyelitis. ∗

Summary

1. Two of 19 monkeys (10.5%) developed poliomyelitis when treated prophylactically with 4-amino-1-naphthol HCl (Naphtoholic derivative). 2. One sample of gallic acid, technical (E-1) (Phenolic derivative) prophylactically protected all of the 12 monkeys treated. A second sample of gallic acid, technical (E-2), freshly prepared, failed to exhibit prophylactic protection. Its mother liquor, however, stored for 50 days allowed only one animal of eleven to develop the disease, when used prophylactically. Of 14 monkeys treated prophylactically with p-aminophenol, 3 developed poliomyelitis. 3. When used therapeutically, both gallic acid, technical (E-1) and mother liquor (E-2) of technical gallic acid, stored at 4°C from one week to 3 months, and given to monkeys beginning 5 days after virus, 7 of 53 monkeys (13%) developed the disease, whereas 47.1% of the controls developed the disease.