Abstract
Summary
Serums from 10 acute cases of infectious hepatitis were inoculated into the allantoic cavity of embryonated eggs. The allantoic fluids from these eggs contained numbers of histiocytes far in excess of the limits detected in uninoculated eggs, and in eggs inoculated with heat-inactivated serums and with icteric serums from cases of obstructive jaundice. This histiocyte promoting factor could not be demonstrated in serums from convalescent patients. No bacteria could be associated with this cellular response. Histiocyte counts engendered through inoculations with acute IH serums were returned to normal limits by gamma globulin, by serums experimentally produced in chickens, and by serums from 3 IH-convalescent patients.
Get full access to this article
View all access options for this article.