Comparison of Excretion Rates of Linear Glutamyl Peptides in Humans and Dogs

Summary

1. Linear glutamyl peptides of number average molecular weight up to 122,-000 are rapidly excreted in the urine of humans and removed from the blood stream in 6 hours or less. In the dog disappearance of these peptides from the plasma is much slower. In this animal the plasma half life time for peptides of number average molecular weight of 57,000 to 122,000 appears to be between 9.5 to 11 hours. 2. Doses of up to 19 g of these peptides had no significant effect on temperature, pulse, respiration, blood pressure, cellular elements or clotting functions of the blood in humans.