Neutralizing Antibody to Viruses of Poliomyelitis in Sera of Domestic Animals

Summary

(1) The sera of cows and steers were shown to possess neutralizing substances in high titer against the viruses of poliomyelitis. These have been shown to be specific antibodies against the viruses of poliomyelitis. (2) The sera of horses, hogs and chickens also possessed modest neutralizing activity against the viruses of poliomyelitis. (3) The sera of dogs, cats, calves and lambs do not possess neutralizing activity against the viruses of poliomyelitis. (4) Attempts to isolate a virus from the bovine species that might explain the origin of these antibodies were unsuccessful. The antigenic stimulus giving rise to antibodies against the viruses of poliomyelitis remains unknown.