Loss and Repair of Glucose-Disposal Mechanism in Dog Fed Fructose As Sole Dietary Carbohydrate. ∗

Summary

1. Our earlier observation in the rat, that the feeding of fructose as sole carbohydrate results in a considerable loss in the animal's capacity to dispose of ingested glucose, is confirmed in another species, the dog. It is also shown that galactose is not the equal of fructose in bringing about impairment in glucose-disposal mechanism. 2. Feeding of a single meal containing 18 g of glucose/kg body weight failed to restore to normal the glucose-disposal mechanism once it was impaired by fructose feeding. A normal capacity for glucose disposal was observed after the dog had ingested 3 glucose-containing meals.