Carbohydrate Metabolism in Experimental Nephrosis

Summary

Urinary glucose, blood glucose, insulin sensitivity and glucose tolerance were measured in experimentally nephrotic rats. In the early stage of nephrosis there was a slight fall in blood sugar concentration, a decrease in glucose tolerance and a decrease in insulin sensitivity. The latter 2 parameters later returned to normal. The response of nephrotic rats to fasting was essentially the same as that of normal rats. The grosser aspects of carbohydrate metabolism appear to be normal in experimental nephrosis.