Effect of Pyrazinamide and Pyrazinoic Acid on Urate Clearance and Other Discrete Renal Functions. ∗ †

Summary

1. The effect of pyrazinamide and pyrazinoic acid on the renal clearance of urate, inulin and p-aminohippurate, in some instances also Tm_PAH, was studied in 10 human subjects. 2. A rapid and marked reduction in urate clearance was noted, without decrease in the filtered urate load. The implications as to the renal mechanisms regulating urate excretion are discussed. 3. Data indicating that the effect of pyrazinamide is ascribable largely to the action of pyrazinoic acid are presented.