Humoral Conditioning for Production of Acute,Massive Myocardial Necroses by Neuromuscular Exertion. ∗

Summary

Following pretreatment with 2-methyl-9(α)-chlorocortisol (Me-Cl-COL), a brief period of neuromuscular effort (induced by force restraint) can elicit acute, massive myocardial necroses in the rat. When NaH₂PO₄ was administered in addition to Me-Cl-COL during the pretreatment period, such changes occurred in 100% of the experimental animals, during or immediately after a period of forced restraint.