Beneficial Effect of Quinoxaline 1,4-di-N-Oxide in Radiation Injury in Mice. ∗

Summary

It has been shown that premedication with Quinoxaline-1,4-di-N-oxide is beneficial to irradiated mice, significantly increasing both the ST₅₀ day and total number of survivors. The effect has been related to a significant reduction in number of enteric organisms causing the usual irradiation bacteremia. It has been demonstrated that lactobacilli were the predominating invaders under conditions of our experiments. The drug does not appear to have an effect on bone marrow.