Uptake of Radiosulphur in Growing Bones of Cockerels Treated with Cortisone and 17-Ethyl-19-Nortestosterone. ∗

Summary

1. The effects of cortisone and 17-ethyl-19-nortestosterone (Nilevar) on radiosulphur uptake by the three long bones of the young cockerel's leg, were investigated. Cortisone diminished and Nilevar increased the binding capacity of labelled sulphate by the growing bones of birds. This was interpreted as the catabolic and anabolic effect of these hormones respectively, on synthesis of certain mucopolysaccharides of growing connective tissue, which specifically incorporate radiosulphur. 2. The anabolic steroid 17-ethyl-19-nortestosterone counteracted the catabolic effect of cortisone on growing bone, when both hormones were administered simultaneously.