Response of Arterial Wall to Intramural Cholesterol. ∗ †

Summary

A technic is described for study of response of avian arteries to intramural injection of cholesterol. This material, when injected into the wall of the artery, causes a foreign body reaction at site of injection. In addition, a localized proliferation of collagenous connective tissue is found in the intima. These intimal plaques resemble some forms of human atherosclerosis. The development of the plaques is not affected by adding cholesterol or various fats to the diet. These findings suggest that the lesions are the result of the local metabolic alteration.