Influence of Long Term Fat-Feeding on Excretion of Cholesterol-4-C 14 Metabolites. ∗

Summary

Effects of long-term feeding of various types and amounts of fat on fecal cholesterol excretion are reported. Diets containing 30% corn oil produce marked acceleration in excretion of C¹⁴ as non-digitonin precipitable neutral sterols in rat feces, accounting in these animals for 17–25% of the administered C¹⁴. This non-digitonin precipitable neutral sterol does not contain a ketonic group and is presumably a 3-alphahydroxy sterol.