Perphenazine (Trilafon ® ) and Chlorpromazine in Experimental Shock. ∗

Summary

1) Pretreatment of rats with perphenazine or chlorpromazine (0.5 − 1.5 mg/kg, im) afforded significant protection against lethal effects of Noble-Collip drum trauma. Chlorpromazine was still effective at doses of 0.2 to 0.4 mg/kg, whereas perphenazine was not protective in this dose range. Pretreatment of dogs with perphenazine (1 mg/kg, iv) significantly protected against lethal effects of hemorrhage under aseptic conditions. Chlorpromazine did not display significant protection at 1 mg/kg, but it did appear to be effective at 3 mg/kg in a limited study. Both drug treated groups (1 mg/kg) bled the same maximal volume as did the controls but at much slower rates when systolic pressure was maintained at 30 mm Hg. 2) Reduction of mortality in pretreated animals subjected to experimental shock may be due, at least in part, to adrenergic blocking activity of the test compounds.