Biological Activity of 9α-Fluoro-ll β -Hydroxy-Δ 4 -Androstene-3,17-Dione. ∗ †

Summary and conclusions

1) FHA (9α-fluoro-11β-hydroxy-Δ⁴-androstene-3,17 -dione) was an effective sodium retaining substance but was inactive in thymolytic and anti-inflammatory tests. This is the first instance of a highly active sodium retaining substance in the C₁₉ series. 2) Introduction of fluorine at the 9α-position in 11β-hydroxy-Δ⁴-androstene-3,17-dione resulted in a compound essentially inactive as an androgen while the uterotrophic activity was intensified as compared to the non-fluorinated steroid.