Abstract
Summary
The effect of 6-deoxy-6-fluoroglucose (6-FG) on oxidation of glucose has been examined in vitro in rat epididymal adipose and rat diaphragm tissue. It was found that 6-FG at all concentrations studied was an effective inhibitor of the oxidation of glucose. However, at high 6-FG concentrations, inhibition curve of glucose oxidation approaches a maximum at approximately 75% and 50% for adipose and diaphragm tissue respectively. The inhibition curve obtained with 2-deoxyglucose, which was used for comparison purposes, appeared to asymptotically approach 100% inhibition of glucose oxidation in these tissues. These results have been interpreted to mean that 2 or more pathways previous to the hexokinase reaction appear to exist for oxidation of glucose in these tissues, and that only one of these pathways is inhibited by 6-FG.
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