Optical Resolution of Mandelic Acid by Complexation with ( S )-(+)-Alanine †

Abstract

Racemic mandelic acid (2) was resolved efficiently by complexation with (S)-(+)-alanine (1) and the crystal structure of 2:2:1 complex of (S)-(+)-alanine (1), (R)-(-)-mandelic acid (2) and H₂O was determined characterizing the hydrogen bond network in the solid state.

Keywords

mandelic acid (s)-(+)-alanine

References

Roger

, J. Chem. Soc., 1935, 1544; A. Collet, J. Jacques, Bull. Soc. Chim. Fr., 1972, 12, 3330; E. J. Valente, W. M. Christopher, J. Zubkowski, D. S. Eggleston, X. Shui, Chirality, 1995, 7, 652.

Ingersoll

A.W.

, J. Am. Chem. Soc., 1933, 55, 411.