2,6-Bis [3-N,N-Dimethylamino-1-Oxopropen-1-Yl]Pyridine as a Building Block in Heterocyclic Synthesis: Synthesis of 2,2′:6′,2″-Terpyridines and 2,6-Bis[Pyrazolyl,Isoxazolyl,Diazepinyl,Pyrazolo[5,1-a]Pyrimidinyl and Pyrazolo-[4,3-D]Pyridazinyl]Pyridines
Free accessResearch articleFirst published online August, 2004
2,6-Bis [3-N,N-Dimethylamino-1-Oxopropen-1-Yl]Pyridine as a Building Block in Heterocyclic Synthesis: Synthesis of 2,2′:6′,2″-Terpyridines and 2,6-Bis[Pyrazolyl,Isoxazolyl,Diazepinyl,Pyrazolo[5,1-a]Pyrimidinyl and Pyrazolo-[4,3-D]Pyridazinyl]Pyridines
A convenient synthesis is reported of some new 2, 2′:6′, 2″-terpyridines, and polycyclic pyridino-2,6-bis-[heterocycles and fused heterocycles] via reaction of 2,6-bis[3-N,N-dimethylamino-1-oxopropen-1-yl]pyridine (2) with various type of nucleophilic reagents. The biological screening showed that many of the prepared compounds have good antibacterial and antifungal activities comparable to Ampicillin and clotrimazoles.
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