Synthesis of Novel 4-Thiazolidinones Linked by an Aryl Spacer to a 1,2,4-Triazine Moiety

A series of potentially biologically active hydrazones, Schiff's base and hybrid thiazolidine-triazine derivatives have been prepared from 4-[(5,6-diphenyl-1,2,4-triazin-3-yl)thio]-benzaldehyde. The latter was prepared by reacting 5,6-diphenyl-1,2,4-triazine-3(2H)-thione with 4-fluorobenzaldehyde. The derivatives were then prepared by condensation of the aldehyde with hydrazines, aniline and various thiazolidin-4-ones. Their structures were established by C,H,N analyses, IR and NMR spectra.