In this paper, we consider the hyperbolic Cahn–Hilliard equation with a proliferation term, which has applications in biology. First, we study the well-posedness and the regularity of the solutions, which then allow us to study the dissipativity and the high-order dissipativity and finally the existence of the exponential attractor with Dirichlet boundary conditions. Finally, we give numerical simulations that confirm the results.
The classical Cahn–Hilliard (CH) equation was proposed in [1,2] in order to describe phase separation processes in binary alloys. During the last decades, it has been analyzed in depth from the mathematical and numerical point of view. It is impossible to quote all the articles related to the mathematical and numerical study of the Cahn–Hilliard equation, the interested ones can see [19]. It is interesting with the Cahn–Hilliard equation in this (or some of its variants) has been used in many other applications, such as deploying in corrosion processes (see [9]), population dynamics (see [5]), tumor growth (see [19]), bacterial films (see [16]), thin films (see [21]), chemistry (see [22]), image processing (see [19]). Recently, researchers have devoted considerable attention to one of its variants which is the hyperbolic relaxation of the Cahn–Hilliard equation. The relaxation term was introduced into the Cahn–Hilliard equation by Galenko et al. (see [6,11–13]), in order to treat more precisely the non-equilibrium effects in the spinodal decomposition generated by fast solidification in some materials (e.g. glasses). It has been studied in [8,14,18,23,24], where the authors proved the existence and uniqueness of the solution, global attractor and a robust family of exponential attractors with appropriate boundary conditions and a regular potential.
We will give a brief description of the relaxed model equations that we will study in this paper with a proliferation term. We assume that an alloy binary is sufficiently cooled to undergo a phase separation process. Naming the relative concentration of one component of the system and the diffusion flux, the balance law for concentration gives
In order to describe the evolution for u, we need to introduce a constitutive assumption on J. On case could be
where is the relaxation parameter and is the total free energy that takes the form as
where ϵ is a positive constant that measures the interfacial width and is a double-well potential accounting for the presence of two components (e.g., ). By combining (1.1) with (1.2), and setting for the sake of simplicity, we obtain
where .
The relaxation term added to the Cahn-Hilliard equation (1.3) changes the type of the equation (from parabolic to hyperbolic) and the analytical properties of its solutions. If , then (1.3) is the classical Cahn-Hilliard equation (see, [1,2,19] and the references therein) for more detail.
Equation (1.3) is usually endowed with boundary and initial conditions on the order parameter, following.
where is the boundary of the domain Ω occupied by the system.
We consider in this paper the following problem
The g function is used for applications in biology, specifically for tumor growth (see [3,4,10,20]).
This article is organized as follows: in Section 2, we present the problem and fix some notations of operators and spaces. In Section 3, we derive a priori estimates which allow us to prove, in Section 3.1, the existence, uniqueness, and the regularity of solution. In Section 3.2, setting of dissipativity and in Section 4, dissipativity in higher-order spaces. In Section 5, the existence of exponential attractors. Then, we finish in Section 6, with the numeral simulations.
Setting of the problem
Let us consider the following initial and boundary value problem in a bounded open interval of , with boundary :
where u is the order parameter, is the relaxation time of the diffusion flow, f is the nonlinear regular potentials and g is a source term.
We make the following assumptions
where
The source term g satisfies
Notations. We denote by the usual scalar product on associated to the norm . Also, we set , where stands for the minus Laplace operator associated with Dirichlet boundary conditions. Noting is equivalent to the usual norm on , where . Besides, denotes the norm on the Banach space X. We set
and
A priori estimates
In this section, we first establish some priori estimates of the system (2.1)–(2.3), which are obtained by formal arguments, and prove the existence and uniqueness of the solution, l’existence of a continuous dissipative semigroup, and obtain some regularity who are essential for the continuation.
We rewrite (2.1) in the equivalent form:
Multiplying (3.1) by , with and integrating over Ω, we obtain
where
Thanks to Cauchy–Schwarz inequality yields
Owing to (2.7), we obtain
Combinig the above estimates in (3.3), we deduce
Thanks to (2.6)–(2.7), we find
Using (2.10), Young’s and Poincaré inequalities, we get
and
Combining the above inequalities, we can rewrite (3.2) as follows
Apply the Gronwall’s lemma to (3.4) (see, eg., [19]), we obtain
We multiply (3.1) by , with and integrating over Ω, we have
where
Thus, for , we deduce
Owing to (2.4)–(2.8), Young’s inequality and , we have
and
Thanks to (2.10), Young’s and Poincaré inequalities, we deduce
and
Combining the above estimates, we can rewrite (3.6) as
Thanks to, , , (3.5), and (3.6), we have
Apply the Gronwall’s lemma to (3.8), we conclude
Existence and uniqueness of solutions
The estimates below allow us to state the following theorem.
For. Assuming (
2.4
)–(
2.8
) and (
2.10
) are holds. Then there exists a solutionof system (
2.1
)–(
2.3
) such that,
The proof of the existence is based on the Galerkin standard method.
Consider a spectral basis of associated with eigenvalues, which forms an orthonormal basis in and orthogonal in . We pose this spectral basis, and
Consider the following approximating problem, written in the functional form
Replacing u by in estimates (3.5) and (3.9), we conclude that
Finally, the passage to the limit is based on classical (Aubin–Lions type) compactness results, we find the result. □
Under the assumption of Theorem
3.1
and for, the solutionis unique.
Consider and two solutions of systems (2.1)–(2.3) with respective initial conditions and in . we pose:
The system (2.1)–(2.3) becomes
Multiplying (3.12) by , with and integrating over Ω, we have
where
Thanks to Cauchy–Schwarz inequality yields
Owing to (2.4)–(2.8), we get
and
Thanks to Young’s inequality, we deduce
Owing to (2.9), Young’s and Poincaré inequalities, we obtain
and
Combining the above estimates in (3.14), we have
Apply the Gronwall’s lemma to (3.15), we conclude
Hence the uniqueness, as well as the continuous dependence with respect to the initial data. □
For , we do not have the uniqueness of the solution for the system (2.1)–(2.3).
Dissipativity
Thanks to Theorem 3.2, we can state the following theorem
Under the assumption of Theorem
3.2
, then the system (
2.1
)–(
2.3
) define a continuous semigroupby the expressionwhereis the solution to (
2.1
)–(
2.3
).
Under the assumption of Theorem
3.1
, the semigroupis dissipative in.
The proof of Corollary follows directly from the estimate (3.5). □
We can assume, without loss of generality, that is positively invariant to , i.e.,
For anyand, there existsuch that, for any two initial datawith, there holdswhereand.
Given two solutions and corresponding to different initial data , the difference fulfills
Multiplying (3.18) by , we have
Thanks to Theorem 3.2, we deduce
Applied the Gronwall’s lemma to 3.20, we obtain the result of Lemma. □
Under the assumption of Theorem
3.2
, and for,then the system (
2.1
)–(
2.3
) has a unique solutionsuch that
Thanks to estimates (3.5), (3.9), we find the result of Theorem 3.8. □
Under the hypotheses of Theorems
3.1
and
3.2
, the Semigroupdefined on the phasehas a global attractorin.
We decompose the semigroup into a sum of two semigroups so that the first tends to 0 when t tends to infinity and the second is asymptotically compact to
Consider the following decomposition
where is the solution of the system
associated with the semigroup {, } and is the solution of the system
associated with the semigroup {, }.
To continue the proof, we need the following lemma.
Under the hypotheses of Theorem
3.1
, the semigroupassociated with system (
3.24
)–(
3.25
) is dissipative in.
We multiply (3.24) by and integrating over Ω, we obtain
where
Thanks to Theorem 3.8 and Holder’s inequality, we find
Combining the above of expression, we deduce
Using the steps in the a priori estimation section, we have
Applied the Gronwall’s to (3.27) and thanks to (3.25), we get
□
Multiplying (3.22) by and integrating over Ω, we deduce
where
Thus, for small enough, we obtain
Owing to (2.4)–(2.8), Young’s and Hölder inequalities, we conclude
and
Thanks to Lemma 3.10, Theorem 3.8 and Young’s inequality, we have
Combining the above estimates, we can rewrite (3.29) as follows
Apply the Gronwall’s lemma to (3.31), we conclude
Thus, the first part of Theorem 3.9 is proved.
The proof of the second part of the Theorem follows directly from the Lemma 3.10. □
The global attractoris bounded in, with a bound independent of.
Dissipativity in higher-order spaces
Our goal in this part is to show that for f and g satisfying compatibility conditions, the semigroup defined on the space (for ) has an absorbing and closed set in . Assume that
and
If , then (4.1)–(4.2) does not add anything to our previous assumptions on f and g. Notice that the derivative of the classical Cahn–Hilliard potential satisfies (4.1) for every .
Let (
4.1
)–(
4.2
) some hold for. Then there existsuch that the closed ballofcentered at zero of radiusis an absorbing set forin. That is, for every bounded set, there existsuch that
The proof of the Theorem follows directly from the proof of the lemma.
Let the hypotheses of Theorem
4.1
hold. Given, there are
andsuch that, ifthe following inequality holds
In this proof, from depended on . We are going to reason by recurrent on n. When it is easy to conclude that (3.5). Hence, assuming that the result holds for , we have
In particular, the assumptions to f yields
Thanks to formula the derivative of a composition of functions of the Faa di Bruno, there is
with if , and
where is a linear combination of terms of the for
for some non-negative integers satisfying
Multiplying (3.1) by , we obtain
where
Thus, for we deduce
Thanks to (4.3) and Young’s inequality, we obtain
and
Combining the above estimates in (4.8), find
Thanks to (4.3), Young’s inequality, we obtain
and
Owing to (4.3)–(4.6), we obtain
and
Moreover
Using (4.3)–(4.5), Young’s inequality, we deduce
and
Finally, collecting the above estimates, we conclude
Thus, for , we deduce
Applying the Lemma 2.1 of [7] to (4.10), we conclude
Hence,
□
□
Actually, up to (possibly) enlarging the radius , the absorbing set is exponentially attracting in as well.
Consider the hypotheses of Theorem
4.1
forhold. Then there existand a positive increasing functionsuch that, for any bounded set,where.
In the proof, we will use the following two lemmas.
Letbe a strongly continuous semigroup on a Banach space Ψ. Letand satisfy thatfor someand. Assume that, for, then holdfor some. Then it follows thatwhere. Here,denotes the usual Hausdorff semidistance in Ψ.
Let (
4.1
)–(
4.2
) some hold for. Then, up to toking a possibly larger, we havefor someand some.
We need to show that the solution map is the sum of a term exponentially decreasing in the space , and a term uniformly bounded in . Adapting the proof of the Theorem 3.9 (in view of the proof of Lemma 4.2), it is immediate to see that the system (3.22)–(3.23) is exponentially stable in , whereas the solution w to (3.24)–(3.25) satisfies the uniform bound
For some c depending on the radius of . Redefining to be greater than or equal to the above constant c, we reach the desired conclusion. □
Till the end of the proof of Theorem 4.3, we agree to redefine inductively the radius so that Lemma 4.5 holds. Then, on account of the Lemma 3.7, Corollary 3.5, and Lemma 4.5, applying recursively Lemma 4.4, we get the result. □
Let (
4.1
)–(
4.2
) some hold for. Then the global attractoris bounded in, with a bound independent of.
We point out that the Hausdorff semidistance in the above theorem is taken in (and not just in ). Clearly, this is a stronger stability result.
Existence of exponential attractors
Provided that (4.1)–(4.2) hold for , there is a robust family of exponential attractors which is uniformly bounded in . Besides, the basin of attraction of each coincides with the whole phase-space . In particular, .
We define the application by
Introduce the lifting maps : as,
Endowing with the metric topology of , it is straightforward to check that is -Holder continuous from into . Indeed, such a Hölder continuity is essential in order to apply the following Lemma 5.3 this is the reason we shall work in .
Let (
4.1
)–(
4.2
) hold for. Then the semigroupspossess compact positively invariant sets“called exponential attractors” with fulfill the following conditions.
There existand a positive increasing functionsuch that, for any bounded set, there holdswhere
The fractal dimension ofis uniformly bounded with respect to.
There existandsuch that
The quantities ω, J, ϵ and C are independent of. Here,is the symmetric Hausdorff distance in.
The proof of the Theorem follows directly from the proof of the following Lemma.
There exist,and(all independent of,such that the following conditions hold.
The mapsatisfies, every,in,where
The lifting mapfulfillswhere:is the projection onto the first component when, and the identity map, otherwise.
For any, there holds
The mapis-Hölder continuous. Besides, the mapis Lipschitz continuous on, with a Lipschitz constant independent ofand.
Throughout the proof of Lemma 5.3, from depend on the radius of the absorbing balls .
Proof of L1. Let , in .
Then we write the difference , where and are the solutions to the following problems
and
Multiplying (5.3) by , we obtain
where
Thanks to Young’s and Poincaré inequalities, we deduce
and
Combining the above estimates, we can rewrite (5.6) as follows
Thanks to Theorem 3.8 and Hölder’s inequality, we obtain
Combinig the above estimates in (5.5), we have
Applying Gronwall’s Lemma to 5.7 and thanks to Lemma 3.7, we conclude
Multiplying (5.1) by and thanks to Theorem (3.9), we obtain
Taking large enough, we deduce
and
fulfill (L1).
Proof of (L2) and (L3). Both assertions follow by the same form
The proof of estimate, we need the following lemma
For, we have the following estimatewhere.
Since is bounded in , then is bounded in . Consider the problem obtained by differentiating with respect to time (3.1) for , that is,
and
where .
It is a standard matter to see that there exists a unique solution for the problem (5.11)–(5.12) in , for any .
We multiply (5.11) by , we obtain
On account of the controls
and
Combining the above estimates, we can rewrite (5.13) as
Applying Gronwall’s lemma to (5.14), we obtain the estimate. □
Let .
We pose
and
We have the following problem
Multiplying (5.11) by , we get
Thanks to Lemma 4.2, Young’s and Poincaré inequalities, we deduce
and
Exploiting the Theorem 3.2 and Lemma 4.2, we conclude
Combining the above estimates in (5.13), we deduce
Thanks to Gronwall’s lemma, Lemma 5.4, we obtain
We will rewrite (5.17), we have
Combinig the above estimates in (5.20),we find
Applying Gronwall’s lemma to (5.21) on , along with (5.19) and Lemma 5.4, we obtain
Thus, we learn that
Thanks to Lemma 4.2 and interpolation inequality, we deduce
Finally, collecting the two above inequalities, we conclude that
Combining (5.22), (5.19) we obtain the estimation result.
Hence, the proof of and .
Proof of the (L4). For any and for any , in view of Lemma 3.7, there holds
Setting , we get at once the second assertion of . In the proof of the first one, we will show that
where, as usual, denotes the first component of .
We multiply (3.1) by , we have
Thanks to Lemma 4.2, we have
Hence, integrating on , we find
Multiplying (3.1) by , we obtain
On account of the above estimates, an integrating over yields the remaining part of (5.23). □
Actually, the coefficient in the Hölder continuity does not need to be independent of to deduce the uniform (with respect to ) finite fractal dimensionality of the family of robust exponential attractors . Recall that the fractal dimension of a (relatively) compact set in a metric space is defined by
where denotes the so-called Kolmogorov μ-entropy of in , being the minimal number of the μ-balls of to cover . So, if the constant in the Hölder continuity is independent of , as it is the case here, we further deduce that the Kolmogorov μ-entropy of the family of robust exponential attractors is, for fixed , bounded from above independently of .
Numerical results
For the numerical simulations of the model, we rewrite (3.1) in the following equivalent form:
where is the relaxation parameter.
Evolution of the solution after every 10 iterations. In this case we take , , and i.e., the classical Cahn–Hilliard equation with the prolifertion term. The time step is .
Evolution of the solution after every 230 iterations. In this case we take , , and i.e., the hyperbolic relaxation of the Cahn–Hilliard equation with the proliferation term. The time step is .
Evolution of the solution after every 50 iterations. In this case we take , , and i.e., the hyperbolic relaxation of the Cahn–Hilliard equation with the proliferation term. The time step is .
Evolution of , and for 70 iterations. In this case we take and , i.e., the classical Cahn–Hilliard equation with the proliferation term. The time step is .
We consider a finite element approach and a semi-implicit Euler time discretization. Let be the triangulation of and the finite element space. We denote by the time step. The variational formulation of the semi-discretized model is as follows.
Let be given and for , find , such that
for all (note that and are not needed).
In the case , the stability result of the scheme (6.1)–(6.2) was obtained in [15,17].
Evolution of , and for 10000 iterations. In this case we take , and i.e., the hyperbolic relaxation of the Cahn–Hilliard equation with the proliferation term. The time step is .
Evolution of , and for 2000 iterations. In this case we take , and i.e., the hyperbolic relaxation of the Cahn–Hilliard equation with the proliferation term. The time step is .
Numerical simulations in one space dimension
The numerical simulations are performed with software Scilab (http://www.scilab.org/). In the numerical results presented below, the domain is . The mesh size is equal to and the time step to . We choose , , , and where and are the growth and death coefficients, respectively, of the tumor cells.
In Figs 1–3, we present the evolution of the solution for different iterations under the influence of the parameters , and .
In Figs 4–6, we show the influence of the parameter’s , and on the evolution of the decomposition of phases. We take the initial condition random on a coarse mesh. In the three cases, the solution u of the (2.1)–(2.3) evolves from to a steady state. The parameter of relaxation corresponds to a typical damping time of the oscillations. We can see in Fig. 5, we put 5 times more time than in Fig. 6 for the damping.
Footnotes
Acknowledgements
The author is thankful to Morgan PIERRE and Alain MIRANVILLE for many helpful discussions.
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