2nd Joint Meeting of the The European Society for Clinical Hemorheology and Microcirculation The International Society for Clinical Hemorheology The International Society of Biorheology July 4–7,2021

July 4, 2021 14:30–15:30 Opening Ceremony 15:40–16:40 Opening Plenary Lecture Chair: Shinya Goto PL1 Coagulopathy and Anticoagulation in Covid-19 - what can we learn for future challenges? Danial Dürschmied Cardiology and Intensive Care Medicine, Heart Center, University of Freiburg, Germany 16:50–17:50 Plenary Lecture for ESCHM Chair: Jean-Frederic Brun PL2 Lessons learnt from comparative hemorheology Ursula Windberger Medizinische Universitaet Wien, Center for Biomedical Research 18:00–19:00 Rising Star Award Session - 1 Chairs: Maria Fornal, Ursula Windberger RSA1-1 Towards elimination of sublethal blood trauma in mechanical circulatory support Michael J Simmonds ^{1,2 1}Menzies Health Institute Queensland, ²Griffith University, Australia RSA1-2 Hemorheological changes caused by pituitary adenylate cyclase-activating polypeptide administration during vessel anastomosis regeneration in the rat Balazs Szabo ¹ , Laszlo Adam Fazekas ¹ , Adam Varga ¹ , Barbara Barath ¹ , Vince Szegeczki ² , Tamas Juhasz ² , Dora Reglodi ³ , Norbert Nemeth ^{1 1}Department of Operative Techniques and Surgical Research, University of Debrecen, Faculty of Medicine, Debrecen, Hungary, ²Department of Anatomy, Histology and Embryology, Faculty of Medicine, University of Debrecen, Debrecen Hungary, ³Department of Anatomy, Faculty of Medicine, University of Pecs, Pecs, Hungary 19:00–20:20 Free Communication (Video Presentation 1) 20:20–21:50 Symposia S1–S3 S1: Microperfusion of different inner organs examined by contrast enhanced ultrasound technology or PET/CT Chair: Dong Yi S1-1 Potential application of dynamic contrast enhanced ultrasound in predicting microvascular invasion of hepatocellular carcinoma Yi Dong ¹ , Yijie Qiu ¹ , Daohui Yang ¹ , Dan Zuo ¹ , Qi Zhang ¹ , Wen-Ping Wang ¹ , Ernst Michael Jung ^{2 1}Zhongshan Hospital, Fudan University, ²Department of Radiology, University Medical Center Regensburg, Germany S2: Clinical hemorheology in critically ill patients Chairs: Shohei Moriyama, Michinari Hieda, Masahito Hitosugi S2-1 Vascular toxicity in cardio-oncology Shohei Moriyama, Michinari Hieda Department of Hematology, Oncology and Cardiovascular Medicine, Kyushu University Hospital S2-2 Catheter treatment of leg arterial atherosclerosis: Endovascular treatment for peripheral arterial disease Eiji Karashima Shimonoseki City Hospital S2-3 Advances in diagnosis and treatment of pulmonary hypertension Kohtaro Abe Department of Cardiovascular Medicine, Kyushu University Hospital S2-4 Myocardial pathological changes in patients with epilepsy and psychiatric disorders Marin Takaso, Misa Tojo, Masahito Hitosugi Department of Legal Medicine, Shiga University of Medical Science S3: Intracellular signaling in RBCs: Roles and consequences Chairs: Özlem Yalçın, Philippe Connes S3-1 Calcium signaling in red cells induced by mechanical stress and flow Lars Kaestner Saarland University S3-2 Shear conditioning attenuates the effects of superoxide in red blood cells: Role of generation and signaling of nitrogen species in different cell subpopulations Marijke Grau ¹ , Lennart Kuck ² , Thomas Dietz ¹ , Michael J Simmonds ^{2 1}German Sport University Cologne, Institute of Cardiovascular Research and Sports Medicine, ²Griffith University Mechanobiology Research Laboratory S3-3 Signaling in erythroid cells: Role in physiology and contribution to pathological manifestations Wassim El Nemer EFS S3-4 Impact of oxidative stress and decreased NO bioavailability on eryptosis and red blood cell microparticles in SCA: Consequences on endothelial cells and vascular function Elie Nader ^1,2 , Marc Romana ^3,4 , Nicolas Guillot ^1,2 , Romain Fort ⁵ , Emeric Stauffer ^1,2,6 , Nathalie Lemonne ⁷ , Yohann Garnier ^3,4 , Sarah Skinner ^1,2 , Maryse Etienne-Julan ⁷ , Mélanie Robert ^1,2,8 , Alexandra Gauthier ^1,2,9 , Giovanna Cannas ⁵ , Sophie Antoine-Jonville ³ , Benoit Tressières ¹⁰ , Marie-Dominique Hardy-Dessources ^3,4 , Yves Bertrand ⁹ , Céline Renoux ^1,2,11 , Philippe Joly ^1,2,11 , Marijke Grau ¹² , Philippe Connes ^{1,2 1}Laboratoire Interuniversitaire de Biologie de la Motricité (LIBM) EA7424, Team “Vascular Biology and Red Blood Cell”, Université Claude Bernard Lyon, Université de Lyon, Lyon, France, ²Laboratoire d’Excellence du Globule Rouge (Labex GR-Ex), PRES Sorbonne, Paris, France, ³Université des Antilles, Pointe-à-Pitre, France, ⁴Université de Paris, Paris, France, ⁵Département de Médecine Interne, Hôpital Edouard Herriot, Hospices Civils de Lyon, Lyon, France, ⁶Centre de Médecine du Sommeil et des Maladies Respiratoires, Hospices Civils de Lyon, Hôpital de la Croix Rousse, Lyon, France, ⁷Unité Transversale de la Drépanocytose, Hôpital de Pointe-à-Pitre, Hôpital Ricou, Guadeloupe, France, ⁸Erytech Pharma, Lyon, France, ⁹Institut d’Hématologie et d’Oncologie Pédiatrique, Hospices Civils de Lyon, Lyon, France, ¹⁰Centre Investigation Clinique Antilles Guyane, 1424 Inserm, Academic Hospital of Pointe-à -Pitre, Guadeloupe, France, ¹¹Laboratoire de Biochimie et de Biologie Moléculaire, UF de Biochimie des Pathologies érythrocytaires, Centre de Biologie et de Pathologie Est, Hospices Civils de Lyon, Lyon, France, ¹²Molecular and Cellular Sport Medicine, Deutsche Sporthochschule Köln, Köln, Germany S3-5 Phosphoproteomic changes in red blood cell membrane by Adenylyl cyclase/Protein kinase A signaling pathway and their roles on the mechanical stress responses of red blood cells Elif Ugurel ^1,2 , Neslihan Cilek ^1,2 , Evrim Goksel ^1,2 , Ozlem Yalcin ^{1,2 1}Koc University School of Medicine Department of Physiology, ²Koc University Research Center for Translational Medicine July 5, 2021 09:10–10:10 Keynote Lecture 1 Chair: Toru Maruyama KL1 Endothelium-dependent hyperpolarization (EDH) and endothelial dysfunction in hypertension: The role of endothelial ion channels Kenichi Goto Kyushu University 09:10–10:10 Keynote Lecture 2 Chair: Takeshi Nakatani KL2 Clinical management of adverse complications in patients with left ventricular assist devices Michinari Hieda Kyushu University 09:10–10:40 Symposium S4 S4: Microfluidic and in silico device applications in hemorheology Chair: Sara Hashmi S4-1 Microfluidic assays to investigate the role of red blood cell-derived extracellular vesicles in sickle cell disease Ran An, Umut Gurkan Case Western Reserve University S4-2 Hemorheology and pathophysiology of COVID-19 induced thrombosis predicted by Vein-Chip Navaneeth Krishna Rajeeva Pandian, Abhishek Jain Texas A&M University 10:20–11:50 Symposia S5–S6 S5: Mechanical circulatory support: From in-development to in vivo Chairs: Michael Simmonds, Tamas Alexy S5-1 The importance of blood rheology in left ventricular assist device therapy Mohammed Chowdhury ¹ , Valmiki Maharaj ² , Arianne Agdamag ² , Blair Edmiston ³ , Bellony Nzemenoh ³ , Victoria Charpentier ⁴ , Tamas Alexy ^{2 1}North Central Heart, Sioux Falls, SD, USA, ²Department of Medicine, Division of Cardiology, University of Minnesota, MN, USA, ³Department of Medicine, University of Minnesota, MN, USA, ⁴University of Minnesota Medical School, Minneapolis, MN, USA S5-2 Hemo-compatibility related adverse events with left ventricular assist device (LVAD) support: Past, present, and future Valmiki Maharaj ¹ , Mohammed Chowdhury ² , Arianne Agdamag ¹ , Blair Edmiston ³ , Bellony Nzemenoh ³ , Victoria Charpentier ⁴ , Tamas Alexy ^{1 1}Department of Medicine, Division of Cardiology, University of Minnesota, MN, USA, ²North Central Heart, Sioux Falls, SD, USA, ³Department of Medicine, University of Minnesota, MN, USA, ⁴University of Minnesota Medical School, Minneapolis, MN, USA S5-3 Analysis of the HeartMate 3 pump characteristics under continuous and pulsatile flow operation – An in vitro study Jo Pauls ^1,2 , Nicole Bartnikowski ^2,3 , E-Peng Seah ² , Clayton Semenzin ² , Martin Mapley ^{2 1}Griffith University - School of Engineering and Built Environment, ²Innovative Cardiovascular Engineering and Technology Laboratory, Critical Care Research Group, The Prince Charles Hospital, ³Queensland University of Technology - Science and Engineering Faculty S5-4 Re-evaluation of blood trauma from a sublethal perspective Michael J Simmonds ^{1,2 1}Menzies Health Institute Queensland, ²Griffith University, Australia S6: Multi-scale diagnosis of biorheology and microcirculation Chairs: Yu Nakamichi, Daisuke Furukawa S6-1 Micro-tomographic visualization of tissue rheological properties by mechanical stimulation using optical coherence tomography Daisuke Furukawa ¹ , Souichi Saeki ^{2 1}Akita Prefectural University, Faculty of Systems Science and Technology, ²Meijo University, Graduate School of Science and Technology S6-2 Three-dimensional detection of hemodynamic changes in skin microcirculation by optical coherence tomography-angiography Yu Nakamichi Sanyo-Onoda City University S6-3 Investigation the extensional effects on the viscosity distribution of bile in the cystic duct Ngoc Minh Nguyen ¹ , Hiromichi Obara ^{2 1}Department of Mechanical Engineering, Thuyloi University, 175 Tay Son, Dong Da, Ha Noi, Vietnam, ²Department of Mechanical Systems Engineering, Tokyo Metropolitan University, 1-1 Minami Osawa, Hachioji, Tokyo, Japan S6-4 Quantitative evaluation of flowing blood with the electrical parameters based on the Hanai mixture equation Yusuke Nakajima ¹ , Daisuke Kawashima ¹ , Ryubu Shoji ¹ , Katsuhiro Matsuura ² , Masahiro Takei ^{1 1}Division of Mechanical Engineering, Chiba University, ²Department of Veterinary Surgery, Tokyo University of Agriculture and Technology S6-5 Development of butterfly type artificial atrioventricular valve with anisotropic valvular cusps by using collagenous connective tissue membrane “Biosheet^®” similar to in vivo tissue architecture Yota Sekido ¹ , Yasuhide Nakayama ² , Tsutomu Tajikawa ^{3 1}Kansai University, Graduate School of Science and Engineering, ²Biotube Co., Ltd, ³Kansai University, Faculty of Engineering Science 12:00–13:00 President-Invited Plenary Lecture - 1 Chair: Toshiro Ohashi PL3 On the path of cell biomechanics research Masaaki Sato Tohoku University 14:20–15:50 Symposia S7–S9 S7: Whole blood behaviour in chips, stents and capillaries Chairs: Andreas Passos, Efstathios Kaliviotis S7-1 Investigation of hemorheological and hematological properties of blood in stented mice Despoina Kokkinidou ^1,2 , Konstantinos Kapnisis ² , Efstathios Kaliviotis ¹ , Andreas Anayiotos ^{2 1}Biorheology Laboratory, Dept. of Mechanical Engineering and Material Science and Engineering, Cyprus University of Technology, Cyprus, ²BioLISYS Laboratory, Dept. of Mechanical Engineering and Material Science and Engineering, Cyprus University of Technology, Cyprus S7-2 Estimation of whole blood coagulation using image processing techniques Marinos Louka ¹ , Antonios Inglezakis ² , Constantinos Loizou ² , Savvas Psarelis ³ , Elena Nikiphorou ⁴ , Efstathios Kaliviotis ^{1 1}Cyprus University of Technology, ²EMBIO Diagnostics Ltd, Nicosia, Cyprus, ³Ministry of Health Cyprus, Nicosia, Cyprus, ⁴King’s College London, King’s College Hospital, London, UK S7-3 Capillary blood flow on a chip: Influence of hemorheological factors.Capillary blood flow on a chip: Influence of hemorheological factors. Dimitris Pasias Pasias, Andreas Passos, Georgios Constantinides, Loukas Koutsokeras, Stavroula Balabani, Efstathios Kaliviotis Cyprus University of Technology S7-4 Erythrocyte sedimentation rate measurements in a high aspect ratio microfluidic channel Andreas Passos ¹ , Antonis Nikolaidis ¹ , Charalampos Vryonidis ¹ , Konstantinos Loizou ² , Antonis Inglezakis ² , Efstathios Kaliviotis ^{1 1}Dept. of Mechanical Engineering and Material Science and Engineering, Cyprus University of Technology, Cyprus, ²EMBIO Diagnostics Ltd, Nicosia, Cyprus S7-5 Influence of hemorheological parameters on the local velocity characteristics of blood in a superehydrophylic channel Efstathios Kaliviotis ¹ , Dimitris Pasias ¹ , Andreas Passos ¹ , Loukas Koutsokeras ¹ , Georgios Constantinides ¹ , Stavroula Balabani ^{2 1}Cyprus University of Technology, ²University College London S8: Mechanobiology of red blood cells Chairs: Michael Simmonds, Jon Detterich S8-1 Role of Piezo1 in red blood cell sickling Elie Nader ^1,2,3 , Aline Hatem ⁴ , Robin Bertot ¹ , Philippe Joly ^1,2,3 , Camille Boisson ^1,2,3 , Guillaume Bouyer ⁴ , Nicolas Guillot ^1,2,3 , Alexandra Gauthier ^1,2,3 , Solène Poutrel ^1,2,3 , Céline Renoux ^1,2,3 , Nicola Conran ⁵ , Flavia Costa ⁵ , Yves Bertrand ³ , Stéphane Égée ⁴ , Philippe Connes ^{1,2,3 1}Laboratoire Interuniversitaire de Biologie de la Motricité (LIBM) EA7424, Team Vascular Biology and Red Blood Cell, Université Claude Bernard Lyon 1, Université de Lyon, Lyon, France, ²Laboratoire d’Excellence du Globule Rouge (Labex GR-Ex), PRES Sorbonne, Paris, France, ³Reference Center in Sickle cell disease, Thalassemia and rare red blood cell and erythropoiesis diseases, Hospices Civils de Lyon, Lyon, France, ⁴UMR 8227 CNRS-Sorbonne Université, Station Biologique, Place Georges Teissier, BP 74, 29682 Roscoff Cedex, France, ⁵Hematology Center, University of Campinas – UNICAMP, Cidade Universitária, Campinas-SP, Brazil S8-2 Shear induced red blood cell nitric oxide production is increased in sickle cell disease Jon A Detterich ^1,2 , Silvie Suriany ¹ , Honglei Liu ¹ , Pinar Ulker ³ , G Esteban Fernandez ¹ , Matthew Borzage ¹ , Rosalinda Wenby ² , Herbert J Meiselman ² , Henry J Forman ⁴ , Thomas D Coates ^{1 1}Children’s Hospital of Los Angeles, ²Keck School of Medicine, University of Southern California, ³Department of Physiology, Akdeniz University, ⁴Department of Gerontology, University of Southern California S8-3 Contribution of red blood cells to pulmonary arterial hypertension pathogenesis: NOS activity and vessel responses Pinar Ulker ¹ , Ibrahim Basarici ² , Nur Özen ¹ , Ece Kilavuz ¹ , Fatih Kisak ¹ , Filiz Basrali ¹ , Nazmi Yaras ³ , Sadi Koksoy ⁴ , Mukadder Levent Celik ⁵ , Leyla Abueid ¹ , Ahmet Yildirim ^{1 1}Department of Physiology, Medical Faculty, Akdeniz University, Antalya, Turkey, ²Department of Cardiology, Medical Faculty, Akdeniz University, Antalya, Turkey, ³Department of Biophysics, Medical Faculty, AkdenizUniversity, Antalya, Turkey, ⁴Department of Medical Microbiology, Medical Faculty, AkdenizUniversity, Antalya, Turkey, ⁵Department of Internal Medicine, University of Health Sciences Antalya Training and Research Hospital, Antalya, Turkey. S8-4 Impaired mechanotransduction in diamide-treated erythrocytes Lennart Kuck ¹ , Jason N. Peart ² , Michael J. Simmonds ^{1 1}Biorheology Research Laboratory, Menzies Health Institute, Griffith University Gold Coast, Queensland, Australia, ²School of Medical Science, Griffith University Gold Coast, Queensland, Australia S9: Hemorheological Measurement and Analysis: RBCs and Platelets Chairs: Sehyun Shin, Dong-Guk Paeng S9-1 Deformability measurement of RBCs flowing in capillary channels using a coflowing channels-based pressure sensor Yang Jun Kang ¹ , Sami Serhrouchni ² , Anna Bogdanova ² , Sung-Sik Lee ^{3 1}Chosun University, ²University of Zürich, ³ETH Zürich S9-2 Numerical study of local parabolic rouleaux formation analyzed by axial and radial shear rates Cheong-Ah Lee ¹ , Dong-Guk Paeng ^{1,2 1}Jeju National University, ²University of Virginia S9-3 Total volume ratio (TVR): A new parameter to evaluate the risk of aneurysm rupture Jinmu Jung ¹ , Ui Yun Lee ¹ , Hyosung Kwak ² , Dongwhan Lee ^{1 1}Division of Mechanical Design Engineering, College of Engineering, Jeonbuk National University, Jeonju, South Korea, ²Department of Radiology, Jeonbuk National University Hospital, Jeonju, South Korea S9-4 Measurement of platelet adhesion by using correlation mapping Eunseop Yeom Pusan National University S9-5 Thrombus formation through upstream activation and downstream adhesion of platelets in a microfluidic system Sehyun Shin ¹ , SeonYoung Kim ² , ByoungKwon Lee ³ , ChaeSeung Lim ^{4 1}Korea University, ²Rheomeditech. Inc., ³Gangnam Severance Hospital, Yeonsei University, ⁴Guro Hospital, Korea University 16:00–17:30 Symposia S10–S12 S10: Rheological models and estimation of prognosis in clinical hemorheology Chairs: Kalman Toth, Peter Kenyeres S10-1 Hemorheological alterations in patients with chronic cerebrovascular disease Peter Kenyeres ¹ , Kinga Totsimon ¹ , Alexandra Nagy ³ , Barbara Sandor ¹ , Katalin Biro ¹ , Laszlo Szapary ² , Kalman Toth ¹ , Zsolt Marton ^{1 1}1st Department of Medicine, University of Pecs, Medical School, Pecs, Hungary, ²Department of Neurology, University of Pecs, Medical School, Pecs, Hungary, ³Department of Behavioral Sciences, University of Pecs, Medical School, Pecs, Hungary S10-2 Novel predictors of future vascular events in post-stroke patients Diana Schrick ¹ , Erzsebet Ezer ¹ , Margit Tokes-Fuzesi ² , Tihamer Molnar ^{1 1}Department of Anaesthesiology and Intensive Therapy, University of Pecs, Medical School, Pecs, Hungary, ²Department of Laboratory Medicine, University of Pecs, Medical School, Pecs, Hungary S10-3 Hemorheological investigations in critically ill patients Zsolt Marton, Zsofia Eszter Szabo, Kinga Totsimon, Kalman Toth, Peter Kenyeres 1st Department of Medicine, University of Pecs, Medical School, Pecs, Hungary S10-4 Maternal hemorheological changes in early-onset preeclampsia Beata Csiszar ^1,2 , Gergely Galos ^1,2 , Peter Kenyeres ^1,2 , Kalman Toth ^1,2 , Barbara Sandor ^{1,2 1}1st Department of Medicine, University of Pecs, Medical School, Pecs, Hungary, ²Szentagothai Research Centre, Pécs, Hungary S10-5 The French paradox - from a rheological point of view Andras Toth ^1,2 , Barbara Sandor ² , Judit Papp ^2,3 , Miklos Rabai ² , Peter Kenyeres ² , Istvan Juricskay ² , Kalman Toth ^{2 1}Department of Medical Imaging, University of Pecs, Medical School, Pecs, Hungary, ²1st Department of Medicine, University of Pecs, Medical School, Pecs, Hungary, ³Hungarian Defence Forces Medical Centre, Budapest, Hungary S10-6 Hemorheological, hematological and histological examination, and 3D flow simulation of arterio-venous fistulas or loop-shaped venous grafts in the rat Balazs Szabo ¹ , Adam Varga ¹ , Barbara Barath ¹ , Souleiman Ghanem ¹ , Orsolya Matolay ² , GyorgyTrencseny ³ , Levente Kiss-Papai ⁵ , Balazs Gasz ⁵ , Lajos Daroczi ⁴ , Norbert Nemeth ^{1 1}Department of Operative Techniques and Surgical Research, University of Debrecen, Faculty of Medicine, Debrecen, Hungary, ²Department of Pathology, Faculty of medicine, University of Debrecen, Debrecen, Hungary, ³Division of Nuclear Medicine, Department of Medical Imaging, Faculty of medicine, University of Debrecen, Debrecen, Hungary, ⁴Institute of Physics, Department of Solid State Physics, Faculty of Physics, University of Debrecen, Debrecen, Hungary, ⁵Department of Surgical Research and Techniques, Faculty of Medicine, University of Pecs, Hungary S11: Known and unknown factors regulating the circulatory system Chairs: Kvetoslava Burda, Maria Fornal S11-1 Association of sulfur concentration in erythrocytes with heart geometry parameters and blood pressure Maria Fornal ¹ , Janusz Lekki ² , Jarosław Krolczyk ¹ , Barbara Wizner ¹ , Tomasz Grodzicki ^{1 1}Jagiellonian University Medical College, Krakow, Poland, ²Institute of Nuclear Physics PAN, Krakow, Poland S11-2 Results of blood research relating to: rheology, morphology and biochemistry of blood in a man living 50 days in extremely low temperatures Zbigniew Joseph Dabrowski ¹ , Aneta Teleglow ¹ , Anna Marchewka ¹ , Maria Fornal ^{2 1}Academy of the Physical Education in Cracow, Poland, ²Collegium Medicum, Jagiellonian University, Krakow, Poland S11-3 Interactions of 𝛽-carotene with red blood cells - its effect on their stability and functioning Joanna Fiedor ¹ , Mateusz Przetocki ¹ , Aleksander Siniarski ^2,3 , Grzegorz Gajos ^2,3 , Nika Spiridis ⁴ , Kinga Freindl ⁴ , Kvetoslava Burda ^{1 1}AGH University of Science and Technology, Faculty of Physics and Applied Computer Science, Krakow, Poland, ²Jagiellonian University Medical College, Krakow, Poland, ³The John Paul II Hospital, Krakow, Poland, ⁴Polish Academy of Sciences, Krakow, Poland S11-4 Correlations between hemorheological parameters in a group of qualified healthy blood donors compared to those in a group of cardiovascular patients. Anna Marcinkowska-Gapinska Department of Biophysics, Karol Marcinkowski University of Medical Sciences in Poznan, Poland S11-5 Can nanoparticles be responsible for the development of hypertension? Kvetoslava Burda ¹ , Joanna Fiedor ¹ , Magdalena Peter ¹ , Mateusz Przetocki ¹ , Jaroslaw Kiecana ^2,3 , Aleksander Siniarski ^2,3 , Grzegorz Gajos ^2,3 , Nika Spiridis ^{4 1}AGH-University of Science and Technology, Krakow, Poland, ²The John Paul II Hospital, Krakow, Poland, ³Jagiellonian University, Medical College, Krakow, Poland, ⁴Jerzy Haber Institute of Catalysis and Surface Chemistry, Polish Academy of Sciences, Krakow, Poland S12: Colloidal models in red blood cell behaviour Chairs: Alexis Darras, Alexander Pribush S12-1 Intricate journey of micro- and nano-carriers for drug delivery in the blood stream Dmitry Fedosov Forschungszentrum Juelich GmbH S12-2 Physical mechanism of erythrocyte sedimentation: Experiments and gel-model Alexis Darras ¹ , Anil Kumar Dasanna ² , Thomas John ¹ , Gerhard Gompper ² , Lars Kaestner ¹ , Dmitry A. Fedosov ² , Christian Wagner ^{1 1}Experimental Physics, Saarland University, 66123 Saarbruecken, Germany, ²Theoretical Physics of Living Matter, Institute of Biological Information Processing and Institute for Advanced Simulation, Forschungszentrum Jülich, 52425 Jülich, Germany S12-3 The erythrocyte sedimentation rate as a diagnostic biomarker for neuroacanthocytosis syndromes Alexis Darras ¹ , Kevin Peikert ^2,3 , Antonia Rabe ^1,4 , François Yaya ^1,5 , Greta Simionato ^1,6 , Thomas John ¹ , Anil Kumar Dasanna ⁷ , Semen Bavalyy ⁷ , Jürgen Geisel ⁸ , Andreas Hermann ^2,3,9,10 , Dmitry A. Fedosov ⁷ , Adrian Danek ¹¹ , Christian Wagner ^1,12 , Lars Kaestner ^{1,4 1}Experimental Physics, Saarland University, 66123 Saarbruecken, Germany, ²Translational Neurodegeneration Section “Albrecht-Kossel”, Department of Neurology, University Medical Center Rostock, University of Rostock, Rostock, Germany, ³Neurodegenerative Diseases, Department of Neurology, Technische Universität Dresden, Dresden, Germany, ⁴Theoretical Medicine and Biosciences, Saarland University, 66424 Homburg, Germany, ⁵Laboratoire Interdisciplinaire de Physique, UMR 5588, 38402 Saint Martin d’Hères, France, ⁶Institute for Clinical and Experimental Surgery, Saarland University, 66424 Homburg, Germany, ⁷Institute of Biological Information Processing and Institute for Advanced Simulation, Forschungszentrum Jülich, 52425 Jülich, Germany, ⁸Central Clinical Laboratory, Saarland University, 66424 Homburg, Germany, ⁹DZNE, German Center for Neurodegenerative Diseases, Research Site Rostock/Greifswald, Rostock, Germany, ¹⁰Center for Transdisciplinary Neurosciences Rostock (CTNR), University Medical Center Rostock, University of Rostock, Rostock, Germany, ¹¹Neurologische Klinik und Poliklinik, Ludwig-Maximilians-Universität, 81366 Munich, Germany, ¹²Physics and Materials Science Research Unit, University of Luxembourg, Luxembourg City, Luxembourg S12-4 Investigating the red blood cell (dis)aggregation mechanism by means of optical tweezers Francois Yaya ^1,2 , Olivera Korculanin ^3,4 , Mehrnaz Babaki ^3,4 , Pavlik Lettinga ^3,4 , Christian Wagner ¹ , Kisung Lee ^{5 1}Experimental Physics, University of Saarland, Saarbrücken, Germany, ²Laboratoire Interdisciplinaire de Physique (LIPhy), CNRS and University of Grenoble, Grenoble, France, ³Biomacromolecular Systems and Processes (IBI-4), Forschungszentrum Jülich GmbH, Jülich, Germany, ⁴Laboratory for Soft Matter and Biophysics, KU Leuven, Leuven, Belgium, ⁵Center for Soft and Living Matter, Institute for Basic Science, Ulsan, South Korea 17:50–18:50 President-Invited Plenary Lecture - 2 Chair: Alberto Caggiati PL4 Pathophysiology and treatment options for venous ulceration: Is there a role for exercise? Markos Klonizakis Lifestyle, Exercise and Nutrition Improvement (LENI) Research Group, Department of Nursing and Midwifery, Sheffield Hallam University, United Kingdom 19:00–20:00 Plenary Lecture for ISCH Chair: Brian Cooke PL5 Hemodynamic functionality of transfused red blood cells - a potent effector of transfusion outcome Saul Yedgar ¹ , Neta Goldschmidt ² , Orly Zelig ² , Axel Pries ³ , Gregory Barshtein ^{1 1}The Hebrew University Medical School, Jerusalem, Israel, ²Hadasah Hospital, Jerusalem, Israel, ³Charite-Free University, Berlin, Germany 20:10–21:40 Symposia S13–S15 S13: Preclinical and clinical studies on blood cells and microcirculation Chair: Anna Maria Blocki S13-1 Nanoparticle-mediated delivery of nucleic acids in primary human endothelial cells Manfred Gossen ^1,2 , Skadi Lau ^1,2 , Hanieh Moradian ^1,2,3 , Marc Behl ¹ , Andreas Lendlein ^{1,2,3 1}Institute of Active Polymers, Helmholtz-Zentrum Hereon, Teltow, Germany, ²Berlin-Brandenburg Center for Regenerative Therapies (BCRT), Berlin, Germany, ³Institute of Biochemistry and Biology, University of Potsdam, 14476 Potsdam, Germany S13-2 Long-term stabilization of three-dimensional perfusable microvascular networks in microfluidic devices Ho-Ying Wan ¹ , Jack Chun Hin Chen ² , Qinru Xiao ² , Christy Wingtung Wong ¹ , Yi-Ping Megan Ho ² , Roger D. Kamm ³ , Sebastian Beyer ² , Anna Maria Blocki ^{1 1}Institute for Tissue Engineering and Regenerative Medicine, The Chinese University of Hong Kong, ²Department of Biomedical Engineering, Faculty of Engineering, The Chinese University of Hong Kong, ³Department of Biology and Mechanical Engineering, Massachusetts Institute of Technology S13-4 Assessment of leukocyte activation in the intestinal microcirculation in a novel model of CNS injury-induced immunodepression Bashir Bietar, Christian Lehmann Dalhousie University S13-5 Experimental Cannabinoid Receptor 2 Modulation for the Treatment of Interstitial Cystitis Geraint Christopher Berger ¹ , Juan Zhou ¹ , Melanie Kelly ^2,1,4 , Christian Lehmann ^{1,2,3,5 1}Department of Anesthesia, Pain Management and Perioperative Medicine, Dalhousie University, ²Department of Pharmacology, Dalhousie University, ³Department of Microbiology & Immunology, Dalhousie University, ⁴Department of Ophthalmology & Visual Sciences, Dalhousie University, ⁵Department of Physiology and Biophysics, Dalhousie University S14: Biorheology and COVID-19 Thrombosis Chairs: Barbara Zieger, Shinya Goto S14-2 Retrospective study of COVID-19-associated coagulopathy in hospitalized patients at Tokai University Hospital Masayuki Oki ¹ , Hideki Yanagi ¹ , Masahiro Kamono ¹ , Saki Manabe ¹ , Akiko Taoda ¹ , Ayumi Tsuda ¹ , Satoshi Abe ¹ , Takako Kobayashi ¹ , Koichiro Asano ² , Yoshihide Nakagawa ¹ , Yasuhiro Kanatani ³ , Hideki Ozawa ¹ , Shinya Goto ^{2 1}Department of General Medicine, Tokai University School of Medicine, ²Department of Internal Medicine, ³Department of Pharmacology S14-3 COVID-19 and thrombosis: the importance of endothelial function Shinichi Goto ^1,2,3 , Shinya Goto ^{3 1}Brigham and Women’s Hospital, Harvard Medical School, ²Keio University School of Medicine, ³Tokai University School of Medicine S15: New useful techniques in disease Chairs: Özlem Yalçın, Philippe Connes S15-1 A novel integrated biomarker for screening diabetic kidney diseases: critical shear stress of RBCs Sehyun Shin ¹ , Junsung Moon ² , Jimi Choi ³ , Sin-Gon Kim ³ , Kyu Jang Won ^{2 1}Korea University, ²Yeungnam University Hospital, ³Korea University Anam Hospital S15-2 Clinical microfluidic biomarker assays for red cell health and blood rheology Umut Gurkan Case Western Reserve University S15-3 Concurrent assessment of deformability and adhesiveness of sickle red blood cells by measuring perfusion of an adhesive artificial microvascular network Madeleine Lu ¹ , Celeste Kanne ^2,3 , Riley Reddington ¹ , Dalia Lezzar ¹ , Vivien Sheehan ^2,3 , Sergey Shevkoplyas ^{1 1}Department of Biomedical Engineering, University of Houston, Houston, TX, USA, ²Aflac Cancer and Blood Disorders Center, Children’s Healthcare of Atlanta, Atlanta, GA, USA, ³Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA S15-4 Usefulness of oxygen gradient ektacytometry in sickle cell disease Philippe Connes ^1,2 , Camille Boisson ^1,2,3 , Minke Rab ^4,5 , Elie Nader ^1,2 , Céline Renoux ^1,2,3 , Philippe Joly ^1,2,3 , Romain Fort ^1,2,6 , Alexandra Gauthier ^1,2,7 , Yves Bertrand ⁷ , Richard van Wijk ⁴ , Vivien Sheehan ⁸ , Eduard van Beers ^{5 1}Laboratoire Interuniversitaire de Biologie de la Motricite (LIBM) EA7424, Team Vascular Biology and Red Blood Cell, Universite Claude Bernard Lyon 1, Universite de Lyon, France, ²Laboratoire d’Excellence du Globule Rouge (Labex GR-Ex), PRES Sorbonne, Paris, France, ³Laboratoire de Biochimie et de Biologie Moleculaire, Lyon, ⁴Central Diagnostic Laboratory - Research, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands, ⁵Van Creveldkliniek, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands, ⁶Departement de Meedecine Interne, Hopital Edouard Herriot, Hospices Civils de Lyon, ⁷Institut d’Hematologie et d’Oncologie Pediatrique, Hospices Civils de Lyon, Lyon, ⁸Department of Pediatrics, Division of Hematology/Oncology, Baylor College of Medicine; Houston Texas, USA S15-5 A novel microfluidics-based point of care technique for viscoelastic hemostatic assay Ozlem Yalcin ¹ , Ahmet Can Erten ² , Berfin Irmak Torun ³ , Fatma Oz ^{3 1}Koc University, School of Medicine, Koç University, Research Center for Translational Medicine (KUTTAM), Istanbul, Turkey, ²Department of Electronics and Communication Engineering, Istanbul Technical University, Istanbul, Turkey, ³Koç University, Graduate School of Biomedical Sciences and Engineering, Istanbul, Turkey July 6, 2021 9:10–10:10 Rising Star Award Session – 2 Chair: Edgar O’Rear, Tamas Alexy RSA2-1 Blood flow thrombosis simulation to understand complex phenomenon of thrombosis under blood flow conditions Shinichi Goto ¹ , Noriko Tamura ³ , Masamitsu Nakayama ² , Shu Takagi ⁴ , Shinya Goto ^{2 1}Brigham and Women’s Hospital, Harvard Medical School, MA, USA, ²Tokai University School of Medicine, Japan, ³Niigata University of Health and Welfare, Japan, ⁴Graduate School of Engineering, The University of Tokyo, Japan RSA2-2 Suspension rheology of red blood cells under oscillatory shear flow Naoki Takeishi ¹ , Marco E Rosti ² , Naoto Yokoyama ³ , Shigeo Wada ¹ , Luca Brandt ^{4 1}Osaka University, ²OIST, ³Tokyo Denki University, ⁴KTH 10:20–11:20 Free Communication (Video Presentation 2) 11:30–12:30 Plenary Lecture for ISB Chair: Peter Butler PL6 Lessons from red blood cell mechanics to endothelial cell mechanobiology Kris N. Dahl Carnegie Mellon University 13:50–14:50 Keynote Lecture 3 Chair: Toshiaki Dobashi KL3 Coagulation of blood: A possible triggering mechanism of the intrinsic coagulation pathway, and assessment of anticoagulant effect of DOACs using a seesaw-type device Makoto Kaibara ¹ , Hiroshi Ujiie ^{2 1}Past affiliation: RIKEN (The Inst. Phys. Chem. Res.), ²Ujiie Neurosurgical & Medical Clinic 13:50–14:50 Keynote Lecture 4 Chair: Nobuo Watanabe KL4 Computational fluid dynamics (CFD) analysis to optimize the design of rotary blood pumps Masahiro Nishida National Institute of Advanced Industrial Science and Technology 13:50–14:50 Keynote Lecture 5 Chair: Toru Maruyama KL5 Dynamics of blood fluidity under various pathologic conditions. The roles of endothelial anticoagulant activities and their pathophysiologic conditions Ikuro Maruyama Department of Systems Biology in Thromboregulation, Kagoshima University Graduate School of Medical and Dental Sciences 15:00–16:30 Symposia S16-S17 / Free Communication (Live presentation) O1 S16: Hemorheological and metabolic properties of red blood cells Chairs: Björn Neu, Olivera Korculanin S16-1 Competition between red blood cell aggregation and breakup: Depletion force due to filamentous viruses vs. shear flow Olivera Korculanin ^1,2 , Tatiana Kochetkova ¹ , Pavlik Minne Paul Lettinga ^{1,2 1}Biomacromolecular Systems and Processes (IBI-4), Forschungszentrum Juelich GmbH, Germany, ²Laboratory for Soft Matter and Biophysics, KU Leuven, Belgium S16-2 Sphingosine-1-phosphate and adenosine affect the oxygen dependence of erythrocyte metabolism Francesco Misiti Cassino and Lazio Meridionale University S16-3 The role of macromolecular depletion on the adhesion of red blood cells with a reduced sialic acid content Björn Neu ¹ , Huimin Teo ² , Zhengwen Zhang ^{2 1}Rhine-Waal University of Applied Sciences, ²Nanyang Technological University S16-4 The Mizar®: A novel, fully-automated aggregometer Lennart Kuck ¹ , Francesco A. Frappa ² , Michael J. Simmonds ^{1 1}Biorheology Research Laboratory, Menzies Health Institute Queensland, Australia, ²Alcor Scientific Inc., Rhode Island, USA S17: Microrheological responses of blood cells under normal and pathological conditions Chairs: Alexei Muravyov, Nadia Antonova S17-1 Development of an experimental microfluidic device and methodology for assessing microrheological properties of blood Nadia Mladenova Antonova ¹ , Khristo Khristov ² , Anika Svilenova Alexandrova ³ , Alexei Vasilievich Muravyov ^{4 1}Dept. Biomechanics, Institute of Mechanics at the Bulgarian Academy of Sciences, Sofia, Bulgaria, ²Institute of Physical Chemistry at the Bulgarian Academy of Sciences, Sofia, Bulgaria, ³Institute of Mechanics at the Bulgarian Academy of Sciences, Sofia, Bulgaria, ⁴Yaroslavl State Pedagogical University Ushinskii, Yaroslavl, Russia S17-2 Comparative study of the microrheological properties of blood in patients with type 2 diabetes mellitus, using viscometry and microfluidic flow analysis Anika Svilenova Aleksandrova-Watanabe ¹ , Nadia Mladenova Antonova ¹ , Alexey Vasilievich Muravyov ² , Khristo Ivanov Khistov ³ , Irena Vasileva Velcheva ^{4 1}Dept. of Biomechanics, Institute of Mechanics, Bulgarian Academy of Sciences, Sofia, Bulgaria, ²Dept. of Medical and Biological Foundations of Sports, Yaroslavl State Pedagogical University named after K. D. Ushinsky, Yaroslavl, Russia, ³Dept. of Interfaces and Colloids, Institute of Physical Chemistry, Bulgarian Academy of Sciences, Sofia, Bulgaria, ⁴Clinic of Nervous Diseases, Uni Hospital, Panagyurishte, Bulgaria S17-3 Microrheological responses of red blood cells (RBCs) to gasotransmitters in persons with different levels of oxygen supply to the body Alexei Vasilievich Muravyov ¹ , Pavel Valentinovich Mikhailov ¹ , Irina Alexandrovna Tikhomirova ¹ , Roman Sergeevich Ostroumov ¹ , Victor Vasilievich Zinchuk ^{2 1}State pedagogical university, Yaroslavl, ²State Medical University, Grodno, Belarus S17-4 Effect of gasotransmitters (NO and H2S) on hemorheology and blood clotting Irina Alexandrovna Tikhomirova ¹ , Elena Petrovna Petrochenko ¹ , Yulia Viktorovna Malysheva ¹ , Alexei Vasiljevich Muravyov ¹ , Alexander Sergeevich Petrochenko ^{2 1}Yaroslavl State Pedagogical University, ²Yaroslavl State Medical University S17-5 Interaction forces of pair interaction of RBCs and their relation to aggregation parameters under normal and pathological conditions Alexander V. Priezzhev ¹ , Andrei E. Lugovtsov ¹ , Alexey N. Semenov ¹ , Larissa I. Dyachuk ² , Petr B. Ermolinskiy ^{1 1}Physics Department of Lomonosov Moscow State University, ²Medical Research and Education Centre of Lomonosov Moscow State University S17-6 Microrheological responses of RBCs after age (density) separation Petr Ermolinskiy ¹ Andrei Lugovtsov ¹ , François Yaya ^2,5 , Lars Kaestner ^2,3 , Christian Wagner ^2,4 , Alexander Priezzhev ^{1 1}Physics Department, Lomonosov Moscow State University, 119991 Moscow, Russia, ²Experimental Physics, Saarland University, 66123 Saarbrücken, Germany, ³Theoretical Medicine and Biosciences, Saarland University, 66123 Saarbrücken, Germany, ⁴Physics and Materials Science Research Unit, University of Luxembourg, L-1511 Luxembourg, Luxembourg, ⁵Laboratoire Interdisciplinaire de Physique, UMR 5588 CNRS and University Grenoble–Alpes, 38058 Grenoble, France 16:40–18:10 Symposia S19–S20 S19: Microcirculation disturbances, blood microrheological properties and functional states of leukocytes Chair: Nadia Mladenova Antonova S19-1 Disturbances in skin temperature oscillations and blood rheological and electrical properties in patients with Diabetes mellitus type 2 Nadia Mladenova Antonova ¹ , Vasilka Krumova Paskova ² , Irena Vasileva Velcheva ³ , Sergey Yurievich Podtaev ^{4 1}Dept. Biomechanics, Institute of Mechanics at the Bulgarian Academy of Sciences, Sofia, Bulgaria, ²Institute of Mechanics at the Bulgarian Academy of Sciences, Sofia, Bulgaria, ³Uni Hospital, Panagyurishte, Bulgaria, ⁴Institute of Continuous Media Mechanics, RAS, Perm, Russia S19-2 Functional states of PMN in pregnant women with hypertension assessed with chemiluminescent method - preliminary data B. Bechev ¹ , M. Magrisso ² , S. Stoeff ¹ , Sv. Jovtchev ¹ , S. Miteva ¹ , S. Alexandrov ¹ , J. Ivanov ¹ , M. Pencheva ³ , D. Koleva ⁴ , I. Buteva ⁴ , M. Vretenarska ⁵ , N. Nikolova ⁶ and V. Iliev ^{6,7 1} Dept Medical Physics and Biophysics and ³Dept Biology of Medical University Sofia, Bulgaria, ²Omrad Electronics LTD, Beer Sheva, Israel, ⁴OGW/MHAT “Nadezhda” Sofia, ⁵2nd MHAT Sofia, Nephrology Ward, ⁶MC Vitclinic, ⁷Military Medical Academy of Sofia S19-3 Participation of polymorphonuclear leukocytes in initiation and evolvement of pathologies induced by SARS-Cov-2 virus B. Bechev ¹ , S. Stoeff ¹ and K. Kavaldzhieva ^{2 1}Dept Medical Physics and Biophysics, ²Dept Biology of Medical University Sofia, Bulgaria S20: Nanomechanical and nanorheological assessments of various diseases Chairs: Malgorzata Lekka, Joanna Zemla S20-1 Search for efficient diagnosis and therapy of resistant BRAF mutated melanoma using biophysical methods Tomasz Kobiela ¹ , Anna Sobiepanek ¹ , Swamy Kasarla ¹ , Weronika Prorok ¹ , Tomasz Gambin ^{2 1}Warsaw University of Technology, Faculty of Chemistry, ²Warsaw University of Technology, Faculty of Electronics and Information Technology S20-2 Rheological properties of biological materials Joanna Zemla ¹ , Claude Verdier ² , Malgorzata Lekka ^{1 1}Institute of Nuclear Physics Polish Academy of Sciences, PL-31342 Krakow, Poland, ²Laboratoire Interdisciplinaire de Physique, Université Grenoble Alpes, CNRS, Grenoble, F-38000, France S20-3 Nanomechanical assessment of cancer cells and solid tumors as a mechanical biomarker Andreas Stylianou ^{1,2 1}European University Cyprus, ²University of Cyprus 16:40–18:30 Free Communication (ePoster) 19:20–20:00 ESCHM-ISCH-ISB Combined Business Online Meeting 20:10–22:00 Symposium S21 S21: Shear stress and red cell rheology Chairs: Edgar O’Rear, Ozlem Yalcin S21-1 Cell age sensitivity of red cells to mechanical stresses and calcium load Lennart Kuck ¹ , Jason N. Peart ² , Oliver Todd ¹ , Michael J. Simmonds ^{1 1}Biorheology Research Laboratory, Menzies Health Institute, Griffith University Gold Coast, Queensland, Australia, ²School of Medical Science, Griffith University Gold Coast, Queensland, Australia S21-2 Senescence and red cell rheology Edgar O’Rear ¹ , James Buerck ¹ , Phillip Coghill ² , Ahmed El Banayosy ³ , Hendra Setiadi ^{3 1}University of Oklahoma, ²VADovations, Inc., ³INTEGRIS Baptist Medical Center S21-3 Asymmetrical erythrocyte morphology to detect sublethal damage Nobuo Watanabe ^1,2 , Antony P. McNamee ³ , Jarod T. Horibin ^3,4 , John F. Fraser ⁵ , Masataka Inoue ² , Masaya Hakozaki ² , Fukuta Matsuzawa ² , Michael J. Simmonds ^{3 1}Biofluid Science and Engineering Laboratory, Dept. of Bio-Science and Engineering, College of Systems Engineering and Science, Shibaura Institute of Technology, Saitama, Japan, ²Biofluid Science and Engineering Laboratory, Systems Engineering and Science, Graduate School of Engineering and Science, Shibaura Institute of Technology, Saitama, Japan, ³Biorheology Research Laboratory, Menzies Health Institute Queensland, Griffith University, Gold Coast, Australia, ⁴Perth Blood Institute, West Perth, Perth, Australia, ⁵Critical Care Research Group, University of Queensland & The Prince Charles Hospital, Brisbane, Australia S21-4 Effects of mechanical heart valves on circulating blood in patients with valvular heart diseases Toru Maruyama ¹ , Michinari Hieda ¹ , Aya Sato ² , Takehiko Fujino ^{2 1}Kyushu University, ²Institute of Rheological Function of Foods, Co. Ltd. S21-5 A structured mechanical risk sensitivity assessment system using red cell deformability and fragmentation parameters Ozlem Yalcin ^1,2 , Elif Ugurel ² , Polat Goktas ¹ , Evrim Goksel ^1,3 , Neslihan Cilek ^1,3 , Dila Atar ^{1 1}Koç University, School of Medicine, Istanbul, Turkey, ²Koç University, Research Center for Translational Medicine (KUTTAM), Istanbul, Turkey, ³Koç University, Graduate School of Biomedical Sciences and Engineering, Istanbul, Turkey S21-6 Measurements of erythrocyte deformation in shear and extensional flows M Keith Sharp ¹ , Mohammad M Faghih ^{2 1}University of Louisville, ²US Food and Drug Administration S21-7 In silico simulation of hemodynamics and blood cell mechanics inside human vasculature Senol Piskin ¹ , Aya Ahmed Faeek Elgebaly ^{2 1}Department of Mechanical Engineering, College of Engineering, Istinye University, Istanbul, Turkey, ²Department of Biomedical Engineering, Faculty of Electrical and Electronics Engineering, Yildiz Technical university, Istanbul, Turkey 20:30–22:00 Symposia S22–S23 S22: Microbiorheology from molecules to tissues Chairs: Daisuke Mizuno, Kengo Nishi S22-1 Motion of molecular motors reflecting rheological properties in cells Takayuki Ariga Yamaguchi University S22-2 Glassy cytoplasm driven by non-thermal forces Kenji Nishizawa ^1,2 , Daisuke Mizuno ^{3 1}IBDM, ²CNRS, ³Department of Physics, Kyushu University S22-3 Metabolism-Dependent Active Diffusion in Living Cells Yujiro Sugino ¹ , Kenji Nishizawa ² , Daisuke Mizuno ^{1 1}Department of Physics, Kyushu University, ²IBDM-CNRS S22-4 Microrheology of a concentrated emulsion as a model cytoplasm Shono Inokuchi, Ryosuke Matsuoka, Daisuke Mizuno Kyushu University S22-5 Non-equilibrium fluctuations in cells report on driving forces and organelle mechanics Kengo Nishi ^1,2 , Sufi Raja ¹ , An Pham ¹ , Fred C MacKintosh ³ , Christoph F Schmidt ^{1 1}Duke University, ²UNC Chapel Hill, ³Rice University S23: Clinical studies using various assays for platelets and hemostasis Chairs: Paul Gurbel, Young-Hoon Jeong S23-1 The Global Thrombosis Test Diana Adrienne Gorog University of Hertfordshire & Imperial College, London S23-2 Thromboelastography: Viscoelastic properties of clot formation and their clinical impact in ASCVD patients Young-Hoon Jeong Gyeongsang National University Changwon Hospital S23-3 Clinical trial with Microfluidic Platelet Function Assays(Anysis-200): Comparison with Turbidity-based Drug Response Assay(Verify-NOW Byoung Kwon Lee ¹ , Miney Cho ¹ , Sehyun Shin ^{2 1}Cardiology, Department of Internal Medicine, Gangnam severance Hospital, Yonsei University, Seoul, Korea, ²Department of Mechanical Engineering, Korea University, Seoul, Korea S23-4 T-TAS 01: A novel flow-based system for hemostasis monitoring Jeffrey Dahlen Fujimori Kogyo Co., Ltd. July 7, 2021 9:00–10:30 Symposia S24–S26 S24: Cell mechanics and cell mechanobiology Chairs: Toshiro Ohashi, Taiji Adachi, Susumu Kudo S24-1 Identification of leader cells in cell migration by filopodia using computer vision Baasansuren Otgon ¹ , Ganbat Danaa ² , Toshiro Ohashi ^{3 1}Graduate School of Engineering, Hokkaido University, Japan, ²Open Education Center, Mongolian University of Science and Technology, Mongolia, ³Faculty of Engineering, Hokkaido University, Japan S24-2 Intracellular tension of osteoblast in collagen gel elicits osteocyte alignment under uniaxially-fixed boundary condition Jeonghyun Kim ¹ , Keiichi Ishikawa ² , Junko Sunaga ² , Taiji Adachi ^{2 1}Nagoya University, ²Kyoto University S24-3 Emulating endothelial dysfunction by mimicking the microenvironment of early atherosclerotic lesions within a microfluidic chip Bomi Gweon ¹ , Yujin Shin ^{2 1}Sejong University, ²Hanyang University S24-4 Enhancement and stabilization of sprouting angiogenesis by curvature-oriented behaviors of mesenchymal stem cells Takanori Sano ¹ , Jun-Ichi Kawabe ² , Yukiko T. Matsunaga ^{1 1}Institute of Industrial Science, The University of Tokyo, ²Asahikawa Medical University S24-5 Mechanism driving hydrostatic pressure-induced endothelial tube formation Daisuke Yoshino Tokyo University of Agriculture and Technology S25: Microparticle and cell behavior in confined fluid flows - 1 Chairs: Masako Sugihara-Seki, Naoki Takeishi, Ryoko Otomo S25-1 Numerical analysis of the inertial migration of red blood cells in a channel Naoki Takeishi ¹ , Hiroshi Yamashita ^1,2 , Naoto Yokoyama ³ , Seki Masako ^1,2 , Shigeo Wada ^{1 1}Osaka University, ²Kansai University, ³Tokyo Denki University S25-2 Droplet breakup limits in simple shear flows Mohamed Shoieb Abdelgawad, Marco Edoardo Rosti Okinawa Institute of Science and Technology S25-3 Swelling and hemolytic behavior of human red blood cells in hypotonic fluid Ryoko Otomo, Ryuta Minami, Kiyoshi Bando Kansai University S25-4 Spectral change of a stress-responsive fluorescent molecule caused by the hydrodynamic stress field of microchannel flow Reiko Kuriyama ¹ , Waka Yamamoto ¹ , Hidetsugu Kitakado ² , Shohei Saito ² , Kazuya Tatsumi ¹ , Kazuyoshi Nakabe ^{1 1}Department of Mechanical Engineering and Science, Kyoto University, ²Graduate School of Science, Kyoto University S25-5 Segregation in shear-thickening materials Alessandro Monti, Marco Edoardo Rosti Okinawa Institute of Science and Technology (OIST) S26: Contributing role of erythrocytes for platelet adhesion and thrombus formation Chair: Shinya Goto S26-1 Important physical regulatory roles of erythrocytes on platelet adhesion under blood flow conditions Noriko Tamura ^1,2 , Kazuya Shimizu ³ , Seiji Shiozaki ² , Kazuyasu Sugiyama ⁴ , Masamitsu Nakayama ² , Shinichi Goto ² , Shu Takagi ³ , Shinya Goto ^{2 1}Department of Health and Nutrition, Niigata University of Health and Welfare, ²Department of Medicine (Cardiology), Research Center for Metabolic Disease, Tokai University School of Medicine and Tokai University Graduate School of Medicine, ³Graduate School of Engineering, The University of Tokyo, ⁴Department of Mechanical Science and Bioengineering, Osaka University School of Engineering Science S26-2 Physical interactions between platelets and erythrocytes play an important role for initial platelet adhesion mediated by the interaction of glycoprotein 1b with von Willebrand factor. Shinichi Goto ^1,2,3 , Noriko Tamura ⁴ , Kazuya Shimizu ⁵ , Masamitsu Nakayama ³ , Shu Takagi ⁵ , Shinya Goto ^{3 1}Brigham and Women’s Hospital, Harvard Medical School, ²Keio University School of Medicine, ³Tokai University School of Medicine, ⁴Niigata University of Health and Welfare, ⁵The University of Tokyo S26-3 Water-ethanol separation with tip charged carbon nanotubes Yuui Ono, Eiji Yamamoto, Kenji Yasuoka Keio University 10:40–12:10 Symposia S27–S28 S27: Microparticle and cell behavior in confined fluid flows - 2 Chairs: Masako Sugihara-Seki, Naoki Takeishi, Ryoko Otomo S27-1 Inertial focusing of red blood cells suspended in blood plasma flowing through square tubes Masako Sugihara-Seki ^1,2 , Saori Tanaka ^{1 1}Kansai University, ²Osaka University S27-2 Role of fluid dynamics in optical trapping Tetsuro Tsuji Kyoto University S27-3 Deformable particle suspensions Marco Edoardo Rosti Okinawa Institute of Science and Technology S27-4 On-chip manipulation for revealing novel aspects of red blood cell mechanics Hiroaki Ito Chiba University S27-5 Measurement of near-wall microparticles motion under the influence of radiation pressure of evanescent field Miyu Inoue, Reiko Kuriyama, Kazuya Tatsumi, Kazuyoshi Nakabe Kyoto University S28: Joint symposium with commons for medicine and engineering japan: Application of high performance computer for biorheology Chairs: Shinya Goto, Kazuo Tanishita S28-1 Protein disintegration as a possible mode of protein dissociation between GP1b𝛼 and VWF in blood flow condition: Insights from steered molecular dynamic simulation. Shinichi Goto ^1,2,3 , Masamitsu Nakayama ² , Shu Takagi ⁴ , Shinya Goto ^{2 1}Brigham and Women’s Hospital, Harvard Medical School, ²Tokai University School of Medicine, ³Keio University School of Medicine, ⁴Graduate School of Engineering, The University of Tokyo S28-2 Salt bridge formation between A1 domain of von Willebrand Factor and Platelet Glycoprotein (GP) Ib𝛼 by molecular dynamics simulations Masamitsu Nakayama, Shinichi Goto, Shinya Goto Tokai University School of Medicine S28-3 Finite element analysis of blood clots through visco-hyperelastic constitutive theories Koichiro Tashiro ^1,2 , Yasuhiro Shobayashi ² , Iku Ota ¹ , Atsushi Hotta ^{1 1}Department of Mechanical Engineering, Keio University, ²Biomedical Solutions Inc. S28-4 Newly developed drug-eluting stent (DES) system for cardiovascular diseases: Hybrid nano-coating technology Terumitsu Hasebe ^1,2 , Shunto Maegawa ^1,3 , Kenta Bito ^1,3 , Yutaka Okamoto ³ , Shunsuke Kamei ¹ , Shota Yamamoto ^1,3 , Kosuke Tomita ¹ , Satoshi Suda ¹ , Kazunobu Hashida ¹ , Tomohiro Matsumoto ¹ , Yoko Usami ^4,1 , Yasutaka Baba ^4,1 , Yutaka Imai ¹ , Atsushi Hotta ^{3 1}Tokai University Hachioji Hospital, Tokai University School of Medicine, ²Keio University Hospital Clinical & Translational Research Center, ³Keio University Faculty of Science and Technology, ⁴Saitama Medical University International Medical Center 12:10–13:10 Plenary Lecture in Tribute to Prof. Akira Kamiya Chair: Joji Ando PL7 Emerging roles of membrane lipids and mitochondria in endothelial cell mechanosensing Kimiko Yamamoto The University of Tokyo 14:00–15:00 Closing Plenary Lecture for ISB Chair: Peter Butler PL8 The mechanotransduction of cancer and blood cells exposed to circulatory levels of fluid shear stress Michael R. King Vanderbilt University 15:00–15:50 Closing Ceremony On-Demand Program Free Communication (Video presentation) O2: Hemorheology in health and disease-1 O2-1 Effects of L-arginine on blood fluidity impaired after high-intensity exercise: An in vitro evaluation Haruchi Namba ¹ , Tatsushi Kimura ² , Hironobu Hamada ¹ , Kiyokazu Sekikawa ¹ , Hatsumi Ishio-Ueoka ¹ , Teruki Kajiwara ¹ , Yoshinobu M Sato ¹ , Fumiya Aizawa ¹ , Takamasa Yoshida ¹ , Naoto Kanda ¹ , Aoi Takagi ^{1 1}Department of Physical Analysis and Therapeutic Sciences, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan, ²Faculty of Early Childhood Education and Care, Ohkagakuen University, Aichi, Japan O2-2 Hematological and hemorheological changes in a model of atherosclerotic disease in rabbits Bence Tanczos ¹ , Viktoria Somogyi ¹ , Mariann Bombicz ² , Bela Juhasz ² , Norbert Nemeth ¹ , Adam Deak ^{1 1}Department of Operative Techniques and Surgical Research, Faculty of Medicine, University of Debrecen, Debrecen, Hungary, ²Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Debrecen, Hungary O2-3 Examination of the hemorheological changes in a rat model of polycystic ovary syndrome Barbara Barath ¹ , Adam Varga ¹ , Adam Attila Matrai ¹ , Pathan Afrin Javed ¹ , Krisztina Deak-Pocsai ² , Norbert Nemeth ¹ , Adam Deak ^{1 1}Department of Operative Techniques and Surgical Research, Faculty of Medicine, University of Debrecen, Debrecen, Hungary, ²Department of Physiology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary O2-4 The hazard of PLGA nanoparticles on intima hyperplasia of vascular restenosis in ApoE-/- mice. Tieying Yin ¹ , Wen Shi ¹ , Atik Rohmana Maftuhatul Fuad, Yanhong Li ¹ , Yang Wang ¹ , Junyang Huang ¹ , Ruolin Du ¹ , Guixue Wang ¹ , Yazhou Wang ^{2 1}Key Laboratory for Biorheological Science and Technology of Ministry of Education, State and Local Joint Engineering Laboratory for Vascular Implants, Bioengineering College of Chongqing University, ²School of medicine, Chongqing University, Chongqing, 400030, China O3: Hemorheology in health and disease-2 O3-1 Is leptin a significant regulator of erythrocyte rheology? Jean-Frederic Brun ¹ , Emmanuelle Varlet-Marie ² , Laurent Vachoud ³ , Bénédicte Marion ² , Céline Roques ² , Eric Raynaud de Mauverger ¹ , Jacques Mercier ^{1 1}PhyMedExp, CNRS UMR 9214, INSERM U1046, University of Montpellier, and Department of Clinical Physiology, ²Institut des Biomolécules Max Mousseron (IBMM) UMR CNRS 5247, Université de Montpellier, Ecole Nationale Supé rieure de Chimie de Montpellier, France, ³Laboratoire de Biophysique & Bio-Analyses, Faculté de Pharmacie, Université de Montpellier, France O3-2 Which sub-compartments of fat mass and fat-free mass are related to blood viscosity factors? Jean-Frederic Brun ¹ , Emmanuelle Varlet-Marie ² , Laurent Vachoud ³ , Bénédicte Marion ² , Céline Roques ² , Eric Raynaud de Mauverger ¹ , Jacques Mercier ^{1 1}PhyMedExp, CNRS UMR 9214, INSERM U1046, University of Montpellier, and Department of Clinical Physiology, ²Institut des Biomolécules Max Mousseron (IBMM) UMR CNRS 5247, Université de Montpellier, Ecole Nationale Supérieure de Chimie de Montpellier, France, ³Laboratoire de Biophysique & Bio-Analyses, Faculté de Pharmacie, Université de Montpellier, France O3-3 A link between storage-related sequence of nanoscale changes in RBC membranes and their biochemical and morphological properties Ewa Szczesny-Malysiak ¹ , Magdalena Kaczmarska ¹ , Katarzyna Bulat ¹ , Anna Zimna ^1,2 , Fatih Celal Alcicek ¹ , Jakub Dybas ¹ , Katarzyna Maria Marzec ^{1 1}Jagiellonian Centre for Experimental Therapeutics, Jagiellonian University, Krakow, Poland, ²Faculty of Pharmacy, Jagiellonian University Medical College, Krakow, Poland O3-4 Investigation of effect of measurement time for transmitted light through blood on relationship between erythrocytes’ sedimentation velocity and aggregation parameters Makoto Higuchi ^1,2 , Nobuo Watanabe ^{1 1}Biofluid Science and Engineering Laboratory, Functional Control Systems, Graduate School of Engineering and Science, Shibaura Institute of Technology, Saitama, Japan, ²Ogino Memorial Laboratory, Nihon Kohden Corporation, Saitama, Japan O4: Red cell deformability in humans and mammalians O4-1 3-D analysis of the deformation of RBCs in a doublet while tuning the interaction Mehrnaz Babaki ^1,2 , Pavlik Lettinga ^{1,2 1}Biomacromolecular Systems and Processes (IBI-4), Forschungszentrum Jülich GmbH, Jülich, Germany, ²Laboratory for Soft Matter and Biophysics, KU Leuven, Leuven, Belgium O4-2 Osmotic gradient ektacytometric parameters in human and seven mammalian species Adam Varga, Barbara Barath, Adam Attila Matrai, Viktoria Somogyi, Adam Deak, Norbert Nemeth Department of Operative Techniques and Surgical Research, Faculty of Medicine, University of Debrecen, Debrecen, Hungary O4-3 Effect of heat stress on macro- and micro-rheological parameters in an experimental model Barbara Barath ¹ , Xenia Ozsvath ² , Viktoria Somogyi ¹ , Adam Varga ¹ , Laszlo Babinszky ³ , Norbert Nemeth ¹ , Adam Deak ^{1 1}Department of Operative Techniques and Surgical Research, Faculty of Medicine, University of Debrecen, Debrecen, Hungary, ²Department of Animal Husbandry, Institute of Animal Health, Biotechnology and Nature, Faculty of Agricultural and Food Sciences and Environmental Management, University of Debrecen, Debrecen, Hungary, ³Non-independent Division of Animal Nutrition, Faculty of Agricultural and Food Sciences and Environmental Sciences, University of Debrecen, Debrecen, Hungary O4-4 In vitro effects of heat-treatment on red blood cell micro-rheology in human and various vertebrate species Adam Attila Matrai ¹ , Gabor Varga ¹ , Bence Tanczos ¹ , Barbara Barath ¹ , Adam Varga ¹ , Laszlo Horvath ² , Zsuzsanna Bereczky ³ , Adam Deak ¹ , Norbert Nemeth ^{1 1}Department of Operative Techniques and Surgical Research, Faculty of Medicine, University of Debrecen, Debrecen, Hungary, ²Department of Pharmaceutical Surveillance and Economics, Faculty of Pharmacy, University of Debrecen, Debrecen, Hungary, ³Division of Clinical Laboratory Science, Department of Laboratory Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary O4-5 Activation of Protein kinase A cascade increases deformability of sickle red blood cells Evrim Goksel ^1,2 , Philippe Connes ^4,5,6 , Camille Boisson ^4,5,7 , Céline Renoux ^4,5,7 , Alexandra Gauthier ^4,5,8 , Romain Fort ^4,5,9 , Elie Nader ^4,5 , Solène Poutrel ^4,5,9 , Ozlem Yalcin ^{1,2,3 1}Research Center for Translational Medicine (KUTTAM), Koç University, Istanbul, Turkey, ²Department of Physiology, Koc University School of Medicine, Istanbul, Turkey, ³School of Medicine, Koç University, Istanbul, Turkey, ⁴Laboratoire Interuniversitaire de Biologie de la Motricité (LIBM) EA7424, Equipe “Biologie Vasculaire et du Globule Rouge”, UCBL1, Villeurbanne, France, ⁵Laboratoire d’Excellence (Labex) GR-Ex, Paris, France, , ⁶Institut Universitaire de France, Paris, France, ⁷Laboratoire de Biochimie et de Biologie Moléculaire, UF de Biochimie des Pathologies Érythrocytaires, Centre de Biologie et de Pathologie Est, Hospices Civils de Lyon, 69500 Bron, France, ⁸Institut d’Hématologie et d’Oncologie Pédiatrique, Hospices Civils de Lyon, 69008 Lyon, France, ⁹Département de Médecine Interne, Hôpital Edouard Herriot, Hospices Civils de Lyon, 69008 Lyon, France. Free Communication (ePoster) P-1 Impaired deformability and association with density distribution of erythrocytes in patients with type 2 diabetes mellitus under treatment Toru Maruyama ¹ , Michinari Hieda ¹ , Takeshi Arita ² , Taku Yokoyama ¹ , Mitsuhiro Fukata ¹ , Takehiko Fujino ³ , Koichi Akashi ^{1 1}Kyushu University, ²Fukuoka Wajiro Hospital, ³BOOCS Clinic P-2 Prognostic significance of red cell distribution width in hospitalized old patients with bacterial infection Toru Maruyama ¹ , Keitaro Nakashima ² , Eiichi Ohgami ² , Kazuhiko Katoh ² , Souichi Yoshitomi ² , Mine Harada ^{2 1}Kyushu University, ²Karatsu Higashimatsuura Medical Center P-3 Results of blood research relating to rheology, morphology and biochemistry of blood in a man living 50 days in extremely low temperatures Aneta Teleglow ¹ , Anna Marchewka ¹ , Maria Fornal ² , Zbigniew Dąbrowski ¹ , Jakub Marchewka ¹ , Bartłomiej Ptaszek ¹ , Mateusz Mardyła ¹ , Dariusz Mucha ¹ , Łukasz Tota ¹ , Marcin Maciejczyk ^{1 1}University of Physical Education, Krakow, Poland, ²Jagiellonian University Medical College, Krakow, Poland P-4 Activation of K⁺ ATP channels is involved additively in NO-induced vasodilation Noriko Iida ex-Department of Neurophysiology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan P-5 Stiffening of the human keratinocytes in response to the cyclic temperature changes Yan Nie ^1,2 , Weiwei Wang ¹ , Xun Xu ¹ , Nan Ma ^1,3 , Andreas Lendlein ^{1,2,3 1}Institute of Active Polymers and Berlin-Brandenburg Centre for Regenerative Therapies, Helmholtz-Zentrum Hereon, ²Institute for Biochemistry and Biology, University of Potsdam, ³Institute of Chemistry and Biochemistry, Free University of Berlin P-6 Extensional rheology of semi-dilute entangled solutions of polyelectrolytes in a cross-slot microchannel Arisa Yokokoji ¹ , Tadashi Inoue ¹ , Atsushi Matsumoto ² , Simon J Haward ³ , Amy Q Shen ^{3 1}Department of Macromolecular Science, Graduate school of Science, Osaka University, Toyonaka, Osaka 560-0043, Japan, ²Department of Applied Chemistry and Biotechnology, University of Fukui, Fukui-shi, Fukui 910-8507, Japan, ³Micro/Bio/Nanofluidics Unit, Okinawa Institute of Science and Technology Graduate University (OIST), Onna, Okinawa 904-0495, Japan P-7 Entrapment dynamics of micro-particles in a Pulmonary Capillary Network (PCN) microfluidic device Merav Belenkovich, Josué Sznitman, Netanel Korin Faculty of Biomedical Engineering, Technion- Israel Institute of Technology P-8 Time-series snapshots of the entire circumferential wall of arteries under pulsatile pressure condition captured by grating-based phase-contrast CT Takeshi Matsumoto ¹ , Hiroyuki Tachibana ² , Masato Hoshino ^{3 1}Tokushima University, ²Kawasaki University of Medical Welfare, ³SPring-8 P-9 Hemorheology and blood coagulation in COVID-19 patients Irina Alexandrovna Tikhomirova ¹ , Mihail Mihajlovich Ryabov ^{2 1}Yaroslavl State Pedagogical University, ²Yaroslavl State Medical University P-10 Extended fibrinolysis times in vitro of clots containing erythrocyte microparticles formed by supraphysiologic shear stress Kylie Foster ^1,2 , James Buerck ¹ , Edgar O’Rear ^{1 1}University of Oklahoma, ²VADovations Inc. P-14 Change in oxygen transport by erythrocytes treated with TiO₂ nanoparticles and functionalized carbon nanotubes Magdalena Peter ¹ , Jarosław Kiecana ² , Aleksander Siniarski ^2,3 , Grzegorz Gajos ^2,3 , Józef Korecki ⁴ , Kvetoslava Burda ^{1 1}UST (University of Science and Technology), Cracow, Poland, ²The John Paul II Hospital, Cracow, Poland, ³Jagiellonian University, Medical College, Cracow, Poland, ⁴Jerzy Haber Institute of Catalysis and Surface Chemistry, Polish Academy of Sciences, Cracow, Poland. P-15 [Withdrawn] P-16 Hemodynamic characteristics of fully polymer bioresorbable scaffolds of rats in different ages Tieying Yin ¹ , Wen Shi ¹ , Atik Rohmana Maftuhatul Fuad ¹ , Yanhong Li ¹ , Yang Wang ¹ , Junyang Huang ¹ , Ruolin Du ¹ , Guixue Wang ¹ , Yazhou Wang ^{2 1}Key Laboratory for Biorheological Science and Technology of Ministry of Education, State and Local Joint Engineering Laboratory for Vascular Implants, Bioengineering College of Chongqing University, ²School of medicine, Chongqing University, Chongqing, 400030, China