Abstract
BACKGROUND:
Anatomical cup implantation is a promising approach in primary total hip arthroplasty (THA) and improves functional outcomes.
OBJECTIVE:
We aimed to evaluate the cup position and functional outcomes in primary THA with preoperative dynamic 3D planning.
METHODS:
We retrospectively reviewed 54 hips in 48 patients who underwent primary THA with anatomical cup implantation (mean follow-up time: 52 months). Cup positions were evaluated based on patient-specific morphology, the acetabular fossa and the combined anteversion test. Functional outcomes were assessed after THA. The paired-sample
RESULTS:
Two hips suffered intraoperative trochanteric fracture, but no hip dislocations occurred. No patients reported groin or thigh pain, and all patients were capable of deep squatting and one-leg standing. The mean Harris hip score, WOMAC score, and physical SF-36 score were 94.46
CONCLUSION:
This study provided evidence for the application of anatomical cup implantation assisted with dynamic 3D planning in primary THA, which restored morphology and improved functional outcomes.
Introduction
Total hip arthroplasty (THA) is a highly successful surgical procedure for treating various end-stage hip diseases [1]. The restoration of native hip anatomy and biomechanics is crucial to achieve a pain-free THA. The Charnley cement THA was reported to increase the socket and stem survival rates when radiographic loosening was defined as the endpoint [2]. Malposition of the hip components can lead to failed THA, resulting in issues such as instability, leg-length discrepancy, impingement and prosthesis aseptic loosening [3, 4, 5, 6, 7].
It is controversial to use Lewinnek Safe Zone (LSZ) or anatomical position in the cup implanted. LSZ has been regarded as a standardized range for the acetabular cup, typically involving cup anteversion between 5∘ and 25∘ and inclination between 30∘ and 50∘ [8]. However, LSZ has been criticized for ignoring combined hip anteversion, postural acetabular orientation changes, and patient-specific morphology [9, 10, 11]. Three-dimensional (3D) anatomical studies of acetabular orientation showed that natural acetabular anteversion ranged from 20.1∘ to 23.2∘ and abduction from 53.6∘ to 56.5∘ [12, 13], which differed from the LSZ. Some studies suggested favorable outcomes with anatomical anteversion and abduction for cup placement [14, 15, 16].
Archbold et al. [17] used the transverse acetabular ligament (TAL) as a guide for acetabular cup orientation in 1000 consecutive THA cases, resulting in a dislocation rate of only 0.6% over a minimum of 8 months follow-up. On the contrary, Epstein et al. [18] reported that the TAL was identified in only 47% of hips and the cup position assisted with TAL was no more accurate than the freehand implantation. Consequently, Ha et al. [16] explored the use of the transverse and anterior acetabular notch (ANN) as bone landmarks for cup placement. Unfortunately, not all patients had the ANN in the acetabular ridge, as there are four distinct configurations, curved, angular, irregular and straight [19].
Li et al. [20] identified the anatomical characteristics of the acetabular fossa as stable, with its central axis serving as a reliable landmark for acetabular abduction alignment. Anatomical cup placement was shown to maintain the hip rotation center and component containment, and restore natural hip biomechanics. Long-term follow-up studies of THA have demonstrated excellent radiological results and prosthesis survival with acetabular anatomic reconstruction [2, 21, 22, 23, 24, 25].
Optimal cup placement is crucial for long-term stability and function in THA. To address the lack of consensus on the ideal position, dynamic 3D-assisted THA has emerged as a promising technique. By utilizing preoperative dynamic 3D planning and advanced imaging, this approach enables precise visualization of the patient’s hip anatomy and facilitates optimal placement of the acetabular cup. Therefore, since 2015, we have been using the acetabular fossa as the landmark for cup implantation in primary THA, assisted by preoperative dynamic 3D planning. To date, no study has applied this technology to restoring hip component position and functional outcomes in THA with anatomical acetabular reconstruction. We hypothesized that acetabular implantation could accurately match patient-specific anatomy with preoperative dynamic 3D planning. The combined anteversion was optimized to ensure hip stability first, followed by assessing anterior cup overhang with direct 3D visualization [26]. Cup and femoral stem anteversion were adjusted until satisfactory cup containment and hip stability were obtained. Finally, the landmarks certified in a 3D model were utilized for precise accurate cup implantation in surgery. In summary, this study aimed to evaluate the cup position in THA targeting patient-specific zones. assisted by preoperative dynamic 3D planning, and to assess the surgical safety and patient functional outcomes after THA.
Materials and methods
Participants
A total of 48 patients (54 hips) were recruited for this retrospective study following ethical approval. All patients underwent primary THA between January 2015 and February 2016. Among them, 42 cases underwent unilateral THA (right 23 hips, left 19 hips), and 6 cases underwent bilateral THA. The surgical indication included femoral neck fracture 21 hips (Garden III 7 hips, IV 14 hips), femoral head osteonecrosis 28 hips (Ficat stage III 10 hips, IV 18 hips), osteoarthritis 4 hips (Kellgreen-Lawrence stage IV). Patients with rheumatoid arthritis, infective arthritis, and developmental hip dysplasia were excluded.
Preoperative dynamic 3D planning
3D pelvic model. A. 3D model of the proximal femur and pelvic. B. Three landmarks determined by the acetabular fossa: UP (upper point), AP (anterior point), and PP (posterior point). C. The cup and femoral trial model implanted with points registration. D. Combined anteversion test with the merged proximal femur and prosthesis internally rotated 45∘.
The preoperative dynamic 3D planning was designed by Medical Engineer Yang Zhi. CT scans were obtained with the patient in a supine position with both legs internally rotated to keep the patellar parallel to the table. Transaxial CT images (DICOM) were transferred to Mimics software (version 10.01, Materialise, Belgium), and the 3D pelvic model was reconstructed. The pelvic and femur were separated (Fig. 1A), and the 3D model was adjusted until the bilateral sciatic notches overlapped. The acetabulum was cut vertically to the central plane of the fossa’s upper role. Three points across the cut plane and the acetabular rim were identified as the upper point (UP), anterior point (AP) and posterior point (PP) (Fig. 1B). The appropriate trial model of acetabular cups (STL) was selected and implanted with Mimics points registration module (Fig. 1C). The femoral prosthesis trial model (STL) was inserted with anteversion determined by the long axis of the femoral neck cut surface. The merged proximal femur and femoral prosthesis were internally rotated 40–45∘ to simulate the combined anteversion test [27, 28] (Fig. 1D). If the anterior cup overhang exceeded 3 mm, the cup anteversion increased and the femoral prosthesis anteversion declined accordingly. The final acetabular position and the corresponding bone landmarks on the rim were recorded.
Operation processes. A. Acetabular exposure assisted with three pins and two Homman retractors. B. Three blush signs after cartilage removal. C. Socket implanted anatomically with secure press fit and ceramic liner inserted. D. Intraoperative combined anteversion test, ensuring the femoral head base is paralleled to the liner surface.
All operations were performed by the same surgeon (ZS) using a posterolateral approach. To obtain complete acetabular exposure, the labrum and TAL were removed. After debridement of central soft tissue and osteophyte, the cotyloid fossa was exposed, and the three landmarks were marked as preoperative dynamic 3D planning (Fig. 2A). Acetabular reaming started with the smallest size (40#) and was directed vertically to the cotyloid fossa. As the anterior and posterior column peripheral cartilage gradually contacted the reamer with increasing size, the final reaming direction changed to the acetabulum opening face. With the identification of three blush signs (Fig. 2B), the cementless cup was implanted, and orientation was adjusted by preoperative certified bone landmarks. Finally, the cup achieved a secure press fit and adequate orientation (Fig. 2C). The ceramic or polyethylene liner was inserted, and the 10∘ lipped polyethylene liner was placed in the posterolateral position. After preparing the femoral canal according to the preoperative design, the stem and femoral head were placed, and the combined anteversion was checked. With the surgical leg internally rotated 40–45∘, the base of the femoral head should be parallel to the liner surface (Fig. 2D). In closure, the posterior capsule and short rotators were repaired through drilled holes in the greater trochanter, and no drainage was applied in all patients. Postoperatively, patients were instructed to walk one day later with the aid of two crutches, and full weight-bearing began 3 days post-surgery. Three months later, all patients were allowed to take deep squatting and one-leg standing exercises.
Follow up evaluation
The Harris hip score (HHS), Western Ontario McMaster Universities osteoarthritis index (WOMAC) and SF-36 were calculated to assess functional outcomes. HHS evaluated functional outcomes and pain levels, while the WOMAC assessed symptoms and functional limitations in hip osteoarthritis patients. The SF-36 measured overall health-related quality of life, covering physical and mental health aspects. These well-established scores provided comprehensive insights into patients’ postoperative functional outcomes, pain, and overall well-being, allowing for an effective evaluation of the surgical approach’s success. The presence of thigh or groin pain, the ability of deep squatting and one-leg standing were evaluated (Fig. 3A). At the last follow-up, the weight-bearing pelvic anterioposterior (Fig. 3B) was obtained and measured with RadiAnt DICOM Viewer (Medixant, Poland).
Follow-up evaluation. A. Deep squatting 4 months after right THA surgery. B. Radiological measurements on weight-bearing pelvic X-ray. AO (acetabular offset), FO (femoral offset), AH (acetabular height), and LL (limp length, distance from the lesser trochanteric tip to the ischium tubercle line), 
The parameters included the acetabular and femoral offset, acetabular height and leg length. The acetabular anteversion and abduction angle in native hips, as well as the cup anteversion and abduction angle post-surgery, were evaluated. The preoperative data were collected during the patients’ preoperative assessments, the postoperative data were obtained immediately after surgery, and the follow-up data were recorded at regular intervals (every year) during the mean follow-up period of 52 months. Preoperative acetabular anteversion was measured in the axial CT through the acetabular fossa center. Post-surgery, the cup anteversion was determined by Lewinnek methods [8] (Fig. 3C). Two authors who did not participate in the surgeries (NL and JH) reviewed the clinical and radiographic assessments independently.
The cup position was determined by the comparison between surgical and contralateral native hips in patients who underwent unilateral THA. Continuous variables were shown as mean
Results
Description of the study participants
All 48 patients (54 hips) were aged ranging from 34 to 81 years, with a mean age of 61.1
Two patients (2 hips, adverse effects rate: 3.7%) suffered greater trochanter fractures intraoperatively (Zimmer, CLS Spotorno stem) and were treated with Kirschner wire plus tension band. No other complications were identified during follow-up, including dislocation, superficial or deep infection, nerve palsies and periprosthetic fractures. At the last follow-up, no hip showed radiographic signs of components loosening (recurrence rate: 0%). All implants were porous-coated cementless components from two manufacturers (LINK-Germany: 32 hips, Zimmer-USA: 22 hips). For the femoral head and liners, there were ceramic to ceramic (17 hips), ceramic to polyethylene (21 hips), and metal to polyethylene (16 hips). The cup size ranged from 46–60 mm (median: 52 mm) in women and 50–60 mm (median: 54 mm) in men.
Results of functional outcomes
Regarding functional outcomes, no patients reported groin or thigh pain, and patients were able to do deep squatting and one-leg standing 6 months post-surgery. The mean HHS was 94.46
Results of the parameters before and after THA
Radiological comparison between surgical and native hips (Mean
Standard Deviation)
Radiological comparison between surgical and native hips (Mean
*Significant differences between the native and surgical hips.
Among the 42 cases who underwent unilateral THA and were evaluated for the hip components position, the comparison results between surgical and native hips were listed in Table 1. The acetabular anteversion and abduction angle in native hips were 16.71
Appropriate cup placement is essential for THA, as it affects implant stability, longevity and hip biomechanics. However, there has been historical controversy regarding ideal cup positioning, and methods for aligning the cup can be categorized into mechanical, anatomical, combined anteversion and lumbopelvic kinematics adjusted alignment [29, 3]. The mechanical alignment philosophy is still considered to be the gold standard, and the LSZ was recommended to keep hip stability in primary THA. However, the primary data from the Lewinnek study had significant limitations when analyzed critically [11]. First, the 300 THA hips were performed by 5 different surgeons, and adequate data were available in only 122 cases (dislocation 9 cases). Second, the most experienced surgeon who performed 190 hips (with 1 dislocation, 0.5%) did not place a significantly greater number of cups within the safe zone. Additionally, a recent follow-up of 9784 primary THAs with 206 dislocations identified that 58% of dislocated hips had a cup within the LSZ [10].
Our study utilized the cotyloid fossa as a reliable landmark for anatomical cup implantation, with three constant points (UP, AP, and PP) that are easily identified. Preoperative dynamic 3D simulation in Mimics software ensured surgical safety by determining these landmarks and the combined anteversion, providing a relatively easy and accurate approach compared to other planning methods [31, 32]. A native acetabular anteversion angle of 16.71∘ was measured in axial CT, which was less than Higgins (23.2∘) and Zhang (20.1∘) using 3D measurements. This difference may be attributed to the variations between 2D and 3D views. For the acetabular abduction, our results (53.22∘) were similar to the reports of Hoggins and Zhang (56.5∘ and 53.6∘). Using anatomical cup implantation assisted with dynamic 3D planning, the acetabular height and femoral offset were restored to match those of the native hip. However, the cup offset (29.67
Literature review on the acetabular cup positioned with anatomical landmarks assistance
Literature review on the acetabular cup positioned with anatomical landmarks assistance
– Not reported, ASIS anterior superior iliac spine, FSZ functional safe zone, TAL transverse acetabular ligament, PSTZ patient-specific target zone, LSZ Lewinnek safe zone, TAN transverse acetabular notch, AAN anterior acetabular notch, MAG mechanical alignment guide, PSI patient-specific instrumentation.
Table 2 provides a literature review of studies on the acetabular cup positioned with anatomical landmarks assistance. McCollum and Gray [35] initially introduced cup positioning based on anatomical landmarks. However, their cups’ abduction was 42.0
Regarding the concern raised about the relatively large cup abduction angle (52.29
Only two studies in the literature performed functional analysis of the anatomical acetabular reconstruction. Sotereanos et al. [36] reported an HHS score of 84 (range: 34–97), while Ha et al. [16] reported a score of 94 (range: 86–100). The HSS score in our study was similar to that reported by Ha et al., at 94.46
This study had some limitations. Firstly, its retrospective design and the inclusion of all eligible patients who underwent anatomical cup implantation with dynamic 3D planning at our hospital may have introduced selection bias. Additionally, the limited sample size may have affected the generalizability of the findings to a broader population. The absence of a calculated sample size might have impacted the statistical power of the study. Furthermore, the lack of long-term follow-up limited our ability to assess factors such as liner wear and prosthesis survival. Moreover, the method’s reliance on preoperative CT scans, without full leg scans, may have introduced some limitations in accurately determining femoral neck anteversion. Lastly, the study’s focus on patients without serious acetabular degeneration or deformity may restrict the applicability of the findings to more complex cases. Future studies with larger sample sizes, formal sample size calculations, and a prospective design are needed to validate and strengthen these results.
This is the first study to evaluate the application of anatomical cup implantation assisted with preoperative dynamic 3D planning in primary THA. We introduced dynamic 3D assisted cup placement in total hip arthroplasty, offering clinicians a personalized and precise technique to enhance surgical outcomes, minimize complications, and improve patient care, while also contributing to the advancement of research in the field.
Ethical approval
The study was approved by the Ethics Committee of the People’s Hospital of Gansu Province (ethics number: 2021-223).
Informed consent
All participants were informed of the study’s purpose and signed an informed consent form.
Funding
None to report.
Data availability statement
The data used to support the findings of this study are available from the corresponding author upon reasonable request.
Footnotes
Acknowledgments
None to report.
Conflict of interest
The authors declare that they have no conflicts of interest.
