Increased expression of long non-coding RNA GLIDR in prostate cancer

Abstract

Prostate cancer (PCa) was one of the most common cancers in males in China. Long non-coding RNAs (lncRNA), a class of non-coding RNAs with more than 200 nucleotides, played key roles in the progression of prostate cancer. GLIDR, a novel long intergenic ncRNA, was found to be upregulated in tumors compared to normal tissues by using publically databases. In the clinical validation cohort, our results showed GLIDR was significantly up-regulated in prostate cancer samples and cell lines. To explore the potential functions of the GLIDR, we constructed gene co-expression networks and applied GO analysis. Our analysis revealed that GLIDR was involved in the regulation of translational elongation, transcription, rRNA processing, RNA splicing, signal transduction, and cell adhesion. Furthermore, a GLIDR-mediated ceRNA network in prostate cancer was also identified. We believed that this study still provided some clues in exploring new therapeutic and prognostic targets for prostate cancer.

Keywords

Prostate cancer GLIDR prognosis ceRNA

References

Chen

, et al., Cancer statistics in China, 2015, CA Cancer J Clin 66 (2016), 115-32.

Misawa

, et al., Androgen-induced lncRNA SOCS2-AS1 Promotes Cell Growth and Inhibits Apoptosis in Prostate Cancer Cells, J BIOL CHEM (2016).

Zhang

, et al., LncRNA HOTAIR Enhances the Androgen-Receptor-Mediated Transcriptional Program and Drives Castration-Resistant Prostate Cancer, CELL REP 13 (2015), 209-21.

Mehra

, et al., A novel RNA in situ hybridization assay for the long noncoding RNA SChLAP1 predicts poor clinical outcome after radical prostatectomy in clinically localized prostate cancer, NEOPLASIA 16 (2014), 1121-7.

J.H.

, et al., Reciprocal regulation of PCGEM1 and miR-145 promote proliferation of LNCaP prostate cancer cells, J Exp Clin Cancer Res 33 (2014), 72.

Pickard

M.R.

, et al., Long non-coding RNA GAS5 regulates apoptosis in prostate cancer cell lines, Biochim Biophys Acta 1832 (2013), 1613-23.

Zhang

, et al., Downregulation of long non-coding RNA HCG11 predicts a poor prognosis in prostate cancer, BIOMED PHARMACOTHER 83 (2016), 936-941.

de Kok

J.B.

, et al., DD3(PCA3), a very sensitive and specific marker to detect prostate tumors, CANCER RES 62 (2002), 2695-8.

Wei

, et al., High PCA3 scores in urine correlate with poor-prognosis factors in prostate cancer patients, INT J CLIN EXP MED 8 (2015), 16606-12.

10.

Wan

, et al., Androgen-induced miR-135a acts as a tumor suppressor through downregulating RBAK and MMP11, and mediates resistance to androgen deprivation therapy, ONCOTARGET (2016).

11.

Wan

, et al., UHRF1 overexpression is involved in cell proliferation and biochemical recurrence in prostate cancer after radical prostatectomy, J Exp Clin Cancer Res 35 (2016), 34.

12.

Aryee

M.J.

, et al., DNA methylation alterations exhibit intraindividual stability and interindividual heterogeneity in prostate cancer metastases, SCI TRANSL MED 5 (2013), 169ra10.

13.

Arredouani

M.S.

, et al., Identification of the transcription factor single-minded homologue 2 as a potential biomarker and immunotherapy target in prostate cancer, CLIN CANCER RES 15 (2009), 5794-802.

14.

Cao

, et al., The long non-coding RNA, SNHG6-003, functions as a competing endogenous RNA to promote the progression of hepatocellular carcinoma, ONCOGENE (2016).

15.

Liu

, et al., LncRNA RSU1P2 contributes to tumorigenesis by acting as a ceRNA against let-7a in cervical cancer cells, ONCOTARGET (2016).

16.

Wang

, et al., Pseudogene PTENP1 Functions as a Competing Endogenous RNA (ceRNA) to Regulate PTEN Expression by Sponging miR-499-5p, Biochemistry (Mosc) 81 (2016), 739-47.

17.

J.H.

, et al., StarBase v2.0: decoding miRNA-ceRNA, miRNA-ncRNA and protein-RNA interaction networks from large-scale CLIP-Seq data, NUCLEIC ACIDS RES 42 (2014), D92-7.

18.

, et al., Decreased expression of LncRNA MIR31HG in human bladder cancer, CANCER BIOMARK (2016).

19.

Kazemzadeh

, et al., LOC100287225, novel long intergenic non-coding RNA, misregulates in colorectal cancer, CANCER BIOMARK 16 (2016), 499-505.

20.

Jiang

C.Y.

, et al., Long non-coding RNA lnc-MX1-1 is associated with poor clinical features and promotes cellular proliferation and invasiveness in prostate cancer, Biochem Biophys Res Commun 470 (2016), 721-7.

21.

Bottcher

, et al., Novel long non-coding RNAs are specific diagnostic and prognostic markers for prostate cancer, ONCOTARGET 6 (2015), 4036-50.

22.

Misawa

, et al., Androgen-induced lncRNA SOCS2-AS1 Promotes Cell Growth and Inhibits Apoptosis in Prostate Cancer Cells, J BIOL CHEM (2016).

23.

, et al., Identification of novel AR-targeted microRNAs mediating androgen signalling through critical pathways to regulate cell viability in prostate cancer, PLOS ONE 8 (2013), e56592.

24.

Budd

W.T.

, et al., Dual Action of miR-125b As a Tumor Suppressor and OncomiR-22 Promotes Prostate Cancer Tumorigenesis, PLOS ONE 10 (2015), e0142373.