Urinary NID2 and TWIST1 methylation to augment conventional urine cytology for the detection of bladder cancer

Jones P.A. and Baylin S.B. , The epigenomics of cancer, Cell 128 (2007), 683-92.

Esteller M. , Epigenetics in Cancer, New England Journal of Medicine 358 (2008), 1148-1159.

Rodriguez-Paredes M. and Esteller M. , Cancer epigenetics reaches mainstream oncology, Nat Med 17 (2011), 330-9.

Feinberg A.P. , Koldobskiy M.A. and Gondor A. , Epigenetic modulators, modifiers and mediators in cancer aetiology and progression, Nat Rev Genet 17 (2016), 284-299.

Jones P.A. , DNA methylation and cancer, Cancer Res 46 (1986), 461-6.

Baylin S.B. and Herman J.G. , DNA hypermethylation in tumorigenesis: Epigenetics joins genetics, Trends Genet 16 (2000), 168-74.

Esteller M. , Corn P.G. , Baylin S.B. and Herman J.G. , A gene hypermethylation profile of human cancer, Cancer Res 61 (2001), 3225-9.

Laird P.W. and Jaenisch R. , DNA methylation and cancer, Hum Mol Genet 3 Spec No (1994), 1487-95.

Lin H.H. , Ke H.L. , Huang S.P. , Wu W.J. , Chen Y.K. and Chang L.L. , Increase sensitivity in detecting superficial, low grade bladder cancer by combination analysis of hypermethylation of E-cadherin, p16, p14, RASSF1A genes in urine, Urol Oncol 28 (2010), 597-602.

Chan M.W. , Chan L.W. , Tang N.L. , Tong J.H. , Lo K.W. , Lee T.L. , Cheung H.Y. , Wong W.S. , Chan P.S. , Lai F.M. and To K.F. , Hypermethylation of multiple genes in tumor tissues and voided urine in urinary bladder cancer patients, Clin Cancer Res 8 (2002), 464-70.

Phe V. , Cussenot O. and Roupret M. , Interest of methylated genes as biomarkers in urothelial cell carcinomas of the urinary tract, BJU Int 104 (2009), 896-901.

Chen H. , Yu Y. , Rong S. and Wang H. , Evaluation of diagnostic accuracy of DNA methylation biomarkers for bladder cancer: A systematic review and meta-analysis, Biomarkers 19 (2014), 189-97.

Bornman D.M. , Mathew S. , Alsruhe J. , Herman J.G. and Gabrielson E. , Methylation of the e-cadherin gene in bladder neoplasia and in normal urothelial epithelium from elderly individuals, The American Journal of Pathology 159 (2001), 831-835.

Florl A.R. , Franke K.H. , Niederacher D. , Gerharz C.D. , Seifert H.H. and Schulz W.A. , DNA methylation and the mechanisms of CDKN2A inactivation in transitional cell carcinoma of the urinary bladder, Lab Invest 80 (2000), 1513-22.

Gonzalgo M.L. , Hayashida T. , Bender C.M. , Pao M.M. , Tsai Y.C. , Gonzales F.A. , Nguyen H.D. , Nguyen T.T. and Jones P.A. , The Role of DNA Methylation in Expression of the p19/p16 Locus in Human Bladder Cancer Cell Lines, Cancer Research 58 (1998), 1245-1252.

Muto S. , Horie S. , Takahashi S. , Tomita K. and Kitamura T. , Genetic and Epigenetic Alterations in Normal Bladder Epithelium in Patients with Metachronous Bladder Cancer, Cancer Research 60 (2000), 4021-4025.

Orlow I. , LaRue H. , Osman I. , Lacombe L. , Moore L. , Rabbani F. , Meyer F. , Fradet Y. and Cordon-Cardo C. , Deletions of the INK4A gene in superficial bladder tumors, Association with recurrence, Am J Pathol 155 (1999), 105-13.

Salem C. , Liang G. , Tsai Y.C. , Coulter J. , Knowles M.A. , Feng A.-C. , Groshen S. , Nichols P.W. and Jones P.A. , Progressive Increases in de Novo Methylation of CpG Islands in Bladder Cancer, Cancer Research 60 (2000), 2473-2476.

Salem C.E. , Markl I.D.C. , Bender C.M. , Gonzales F.A. , Jones P.A. and Liang G. , PAX6 methylation and ectopic expression in human tumor cells, International Journal of Cancer 87 (2000), 179-185.

Catto J.W.F. , Azzouzi A.-R. , Rehman I. , Feeley K.M. , Cross S.S. , Amira N. , Fromont G. , Sibony M. , Cussenot O. , Meuth M. and Hamdy F.C. , Promoter Hypermethylation Is Associated With Tumor Location, Stage, and Subsequent Progression in Transitional Cell Carcinoma, Journal of Clinical Oncology 23 (2005), 2903-2910.

Maruyama R. , Toyooka S. , Toyooka K.O. , Harada K. , Virmani A.K. , Zochbauer-Muller S. , Farinas A.J. , Vakar-Lopez F. , Minna J.D. , Sagalowsky A. , Czerniak B. and Gazdar A.F. , Aberrant promoter methylation profile of bladder cancer and its relationship to clinicopathological features, Cancer Res 61 (2001), 8659-63.

Horikawa Y. , Sugano K. , Shigyo M. , Yamamoto H. , Nakazono M. , Fujimoto H. , Kanai Y.A.E. , Hirohashi S. , Kakizoe T. , Habuchi T. and Kato T. , Hypermethylation of an E-Cadherin (CDH 1) Promoter Region in High Grade Transitional Cell Carcinoma of the Bladder Comprising Carcinoma In Situ, The Journal of Urology 169 (2003), 1541-1545.

Renard I. , Joniau S. , van Cleynenbreugel B. , Collette C. , Naome C. , Vlassenbroeck I. , Nicolas H. , de Leval J. , Straub J. , Van Criekinge W. , Hamida W. , Hellel M. , Thomas A. , de Leval L. , Bierau K. and Waltregny D. , Identification and validation of the methylated TWIST1 and NID2 genes through real-time methylation-specific polymerase chain reaction assays for the noninvasive detection of primary bladder cancer in urine samples, Eur Urol 58 (2010), 96-104.

Abern M.R. , Owusu R. and Inman B.A. , Clinical performance and utility of a DNA methylation urine test for bladder cancer, Urol Oncol 32 (2014), 51.e21-6.

Li K. , Lin T. , Fan X. , Duan Y. and Huang J. , Diagnosis of narrow-band imaging in non-muscle-invasive bladder cancer: a systematic review and meta-analysis, Int J Urol 20 (2013), 602-9.

Osborne J.W. , Improving your data transformations: Applying the Box-Cox transformation, Practical Assessment, Research, and Evaluation 15 (2010), 1-9.

DeLong E.R. , DeLong D.M. and Clarke-Pearson D.L. , Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach, Biometrics 44 (1988), 837-45.

Fawcett T. , An introduction to ROC analysis, Pattern Recogn Lett 27 (2006), 861-874.

Pepe M.S. , The Statistical Evaluation of Medical Tests for Classification and Prediction, Oxford University Press, New York, 2003.

Marshall R.J. , The predictive value of simple rules for combining two diagnostic tests, Biometrics 45 (1989), 1213-1222.

Robin X. , Turck N. , Hainard A. , Tiberti N. , Lisacek F. , Sanchez J.C. and Muller M. , pROC: An open-source package for R and S+ to analyze and compare ROC curves, BMC Bioinformatics 12 (2011), 77.

R Development Core Team, R: A Language and Environment for Statistical Computing, R Foundation for Statistical Computing, Vienna, 2011.

van Rhijn B.W. , van der Poel H.G. and van der Kwast T.H. , Urine markers for bladder cancer surveillance: A systematic review, Eur Urol 47 (2005), 736-48.

Yu J. , Zhu T. , Wang Z. , Zhang H. , Qian Z. , Xu H. , Gao B. , Wang W. , Gu L. , Meng J. , Wang J. , Feng X. , Li Y. , Yao X. and Zhu J. , A novel set of DNA methylation markers in urine sediments for sensitive/specific detection of bladder cancer, Clin Cancer Res 13 (2007), 7296-304.

Tobacco smoke and involuntary smoking, IARC Monogr Eval Carcinog Risks Hum 83 (2004), 1-1438.

Philibert R.A. , Beach S.R. and Brody G.H. , The DNA methylation signature of smoking: An archetype for the identification of biomarkers for behavioral illness, Nebr Symp Motiv 61 (2014), 109-27.

Breitling L.P. , Yang R. , Korn B. , Burwinkel B. and Brenner H. , Tobacco-smoking-related differential DNA methylation: 27K discovery and replication, Am J Hum Genet 88 (2011), 450-7.

Zeilinger S. , Kuhnel B. , Klopp N. , Baurecht H. , Kleinschmidt A. , Gieger C. , Weidinger S. , Lattka E. , Adamski J. , Peters A. , Strauch K. , Waldenberger M. and Illig T. , Tobacco smoking leads to extensive genome-wide changes in DNA methylation, PLoS One 8 (2013), e63812.