Overexpression of Anillin (ANLN) is correlated with colorectal cancer progression and poor prognosis

Abstract

BACKGROUND:

Our previous study found ANLN was over-expressed in colorectal cancer(CRC), however the role of ANLN in CRC remained unknown.

OBJECTIVE:

To investigate the relationship of ANLN expression in CRC with clinical features and to determinate the prognostic significance of ANLN expression in CRC.

METHODS:

The ANLN expression in CRC tissue and adjacent normal colorectal mucosa were measured, the relationship between ANLN expression and clinical features as well as overall survival were analyzed.

RESULTS:

ANLN was overexpressed in CRC. ANLN expression was associated with tumor invasion and enlarged tumor size. Furthermore, Kaplan-Meier survival analysis revealed that higher expression of ANLN was associated with poorer overall survival. Multi-variate analysis suggested that higher expression of ANLN, preoperative CEA level and distant metastasis were independent prognostic factor in patients with CRC

CONCLUSIONS:

ANLN expression is elevated in CRC and has a strong potential to act as a biomarker for the prognosis of CRC.

Keywords

Colorectal cancer ANLN prognosis

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