Opposite effects of low‐density and high‐density lipoprotein on blood viscosity in fasting subjects

Given the enlarging body of evidence implicating increased blood viscosity in atherogenesis, the authors hypothesize that lipoproteins modulate the atherogenic process by affecting blood viscosity. In order to define the magnitude of the effect of lipoproteins on blood viscosity, capillary viscometry was performed on blood from 16 healthy, fasting subjects, and results were correlated with lipoprotein‐cholesterol levels. Low‐density lipoprotein‐cholesterol was positively associated with blood viscosity ( r= 0.610 , p= 0.01 ). High‐density lipoprotein‐cholesterol was negatively associated with blood viscosity ( r= -0.479 , p=0.06 ). A multiple regression model was developed with these data, revealing that 54% of variation in blood viscosity was attributable to these lipoproteins. This model was validated on a second dataset, in which these lipoproteins accounted for 28% of variation in blood viscosity. A second model, including hematocrit, serum viscosity, and high‐density lipoprotein‐cholesterol levels, explained 73% of variation in blood viscosity. By modulating blood viscosity and flow, lipoproteins may affect the residence time of atherogenic particles and atherogenesis.