(Aim) Abnormal breast can be diagnosed using the digital mammography. Traditional manual interpretation method cannot yield high accuracy. (Method) In this study, we proposed a novel computer-aided diagnosis system for detecting abnormal breasts in mammogram images. First, we segmented the region-of-interest. Next, the weighted-type fractional Fourier transform (WFRFT) was employed to obtain the unified time-frequency spectrum. Third, principal component analysis (PCA) was introduced and used to reduce the spectrum to only 18 principal components. Fourth, feed-forward neural network (FNN) was utilized to generate the classifier. Finally, a novel algorithm-specific parameter free approach, Jaya, was employed to train the classifier. (Results) Our proposed WFRFT + PCA + Jaya-FNN achieved sensitivity of 92.26% ± 3.44%, specificity of 92.28% ± 3.58%, and accuracy of 92.27% ± 3.49%. (Conclusions) The proposed CAD system is effective in detecting abnormal breasts and performs better than 5 state-of-the-art systems. Besides, Jaya is more effective in training FNN than BP, MBP, GA, SA, and PSO.
