Abstract
Intravenous Immunoglobulin G (IVIG) is one of the most important and widely used human plasma fractions. Although of this there are some precautions should be considered to use this product; e.g. biochemical, biological, immunological, and safety (virus transmission) for each produce patch. The aim of this study was to investigate four commercial IVIG preparations used in Egyptian hospitals. The results show that IVIG from Korean Green Cross Cooperation and Octapharma contained 100% intact IgG, while IVIG-VACSERA and VIGAM-S contained 98--99% IgG subclass distribution corresponded to the distribution in normal human plasma, except for IVIG-VACSERA, where IgG2 slightly elevated. IVIG-VACSERA and VIAGM-S contained acceptable traces of IgA/IgM, while preparations from both Korean Green Cross Cooperation and Octapharma contained 130/150 and 100/80 μg/ml, respectively. Each preparation had a strong potential to react with respiratory and enteric bacterial LPS and tetanus toxoid antigen. Our results are in general agreement with previous status of worldwide diphtheria immunity status. The immunoreactivity with the other antigen will discuss.