Brain Metabolic,Structural,and Behavioral Pattern Learning for Early Predictive Diagnosis of Alzheimer’s Disease

[Journal of Alzheimer’s Disease 63(3), 2018, 935-939, DOI 10.3233/JAD-180063] https://content.iospress.com/articles/journal-of-alzheimers-disease/jad180063

A supplementary figure was missing from this article. On page 936, left column, in line 16, the reference to this figure should have been included.

Article text: Close scrutiny of metabolic patterns through advanced processing of in vivo MRS data has validated the existence of two conformers, extended (GSH_ex) and closed (stable) (GSH_cl) forms of GSH in human brain, which has been first time investigated and found with its exclusiveness from well-established other metabolites such as NAA and aspartate (Figure below).

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Fig.1

Detection of the two (extended and closed) in vivo GSH conformer peaks (GSH_ex and GSH_cl) in healthy control subject using MEGA-PRESS experiment. Data was collected using 3T Philips scanner at NBRC. Data acquisition was performed with following parameters: TE = 130 ms, TR = 2500 ms, (A) MEGA-ON/OFF = 4.40 ppm/5.00 ppm and, (B) MEGA-ON/OFF = 4.56 ppm/5.00 ppm) (voxel size = 3.5×3.5×3.5 cm³ on right frontal cortex).