Abstract
The magnetic nanoparticles in AC alternating magnetic fields will produce a large amount of heats due to the Néer relaxation. Magnetic Fluid Hyperthermia (MFH), based on this mechanism, offers a new breakthrough and has a promising potential in tumor treatments. The temperature field distribution in the treatment and neighbor regions has a significant effect on the therapeutic result. Therefore, it is essential to control the temperature in the treatment region in a proper range (42°C∼90°C) while to guarantee a sharp gradient in the boundary of the treatment and normal regions. This study provides an automatic shape design methodology using the Finite Element Analysis (FEA) of the electromagnetic-temperature Coupled Field (CF) and a multi-objective Particle Swarm Optimization (MOPSO), to realize sufficient uniformities in the temperature field distribution while to ensure the enough temperature gradient in the cancer boundary.