Abstract
This special edition of the Journal of Neuromuscular Diseases marks the inauguration of the John Walton Centre for Neuromuscular Diseases atNewcastle University in the north east of England on the 24th November 2014. The Institute of Genetic Medicine hosted the event which brought together world leaders in the field of neuromuscular disorders – both past and present – to celebrate the remarkable and on-going contribution made by Lord Walton of Detchant to the field of neuromuscular disorders, from his early work as a junior researcher in Newcastle upon Tyne over 50 years ago, through to his pivotal role in the UK Parliament.
The following articles describe the recent ground breaking scientific discoveries in the field of neuromuscular diseases that were presented at the International Centre for Life less than 10 miles from Rowlands Gill, the place with John Nicholas Walton was born in 1922. At the time, his father was a headmaster of Middlestone Primary School, before a promotion led the family to move to the north Durham coalmining community of Spennymoor. There John spent much of his childhood whilst attending Alderman Wraith Grammar School. Having secured a place as a medical student in 1941, the Royal Air Force turned down his application to serve King and Country in combat, realising the critical contribution new doctors would make to the war effort. John therefore made the short trip to Newcastle, where the medical school was part of King’s College, University of Durham. He qualified in medicine in 1945, working initially as House Officer to Professor Nattrass, and then Professor James Spence. Remarkably, his annual salary doubled between the first and second year as a junior doctor – from £50 to £100.
Called for military service in 1947, Dr. Walton was the Embarkation Medical Officer in Glasgow and later in Southampton, before becoming Second-in-Command of the Hospital Ship Oxfordshire. During that time he visited many Mediterranean ports and was involved in the final evacuation of Haifa Military Hospital and of British troops leaving Palestine in 1948. His interest in neuromuscular research began in 1950 s, again working with Fred Nattrass he published the landmark classification of neuromuscular diseases in the journal Brain [1]. In this way Dr Walton became one of the founding fathers of modern myology, and he established a model of continuously improving his clinical practice through scientific enquiry. Now commonplace, this model had its foundations in the careful clinical observation of patients followed by appropriate clinical investigations, which often involved a muscle biopsy analysed by the clinician in juxtapositionary laboratories. As a Consultant Neurologist, he documented the inheritance pattern of different phenotypes which laid the foundations for future genetic linkage, exome and whole genome studies, paving the way for gene-based therapies for muscular dystrophies.
His ethos permeated the national neurology scene, in no small part through his central role developing regional neurology services throughout the United Kingdom. In 1958, and only two miles from the recent inaugural event, he established the first Regional Neurosciences Centre in the North of England. Integrating the clinical service with neuromuscular research laboratories, this became an international hub for trainees in the field of neuromuscular diseases. Many past pupils of John Walton were present at the symposium in 2014, travelling from all four corners of the globe. After a period of time studying with him in Newcastle in the 1950 s and 1960 s, they returned to their homelands and established neuromuscular centres in the image of the Newcastle unit. Many of these centres have gone from strength to strength, and underpin global efforts to develop new treatments for inherited and acquired neuromuscular diseases.
In recent years, patients have taken an increasingly prominent role in the design and implementation of translational research programmes. Junior colleagues may think that this is an innovation, but nothing could be further from the truth, and Professor John Walton was one of the early stalwarts. Back in the 1950 s he co-founded the Muscular Dystrophy Campaign (now Muscular Dystrophy UK), of which he is now Honorary Life President. In those early days he realised that harnessing “patient power” to set the research agenda provided the most powerful influence, ensuring that the patients needs were at the centre of any disease-based research, and encouraging investment in clinical research from the Government and the charity sector. It is difficult, if not impossible, to gage the knock-on effects of this work several decades down the line.
Whilst charting new clinical and pathological phenotypes, he spent 10 years as Dean of the Newcastle Medical School from 1971– 1981 and increasingly played a key part in the development of British medicine through his roles as President of the General Medical Council, the British Medical Association and the Royal Society of Medicine. His adept persuasive skills and solid chairmanship led to similar success on the international stage as President of the World Federation of Neurology and other organisations. As a consequence he was knighted by Queen Elizabeth II in 1979 for his services to medicine.
With his children having left home, and spending increasingly large amounts of time addressing national and international issues, it became clear to his late wife Betty that John was spending more time away from the North East of England than he was here. They therefore moved to Green College, Oxford, there he served as Warden from 1983 until 1989. That same year he was made a life peer, and Baron Walton of Detchant took up his place in the House of Lords where he continues to sit as a cross-bencher (i.e. with no political affiliation) [2]. In 1992 he became a member of the Science and Technology Committee, leaving in 1996 and returning again in 1997. From 1993 he was Chair of the Medical Ethics Committee, and since 2009 has been Secretary of the Rare Disease Group. He made a significant contribution to the Lords debate on mitochondrial transfer, of which he has been a strong supporter, and he has also been outspoken on end of life issues that have recently been in the public eye. Now aged 92 years, Lord Walton remains highly active in the Upper House of Parliament providing both clinical and scientific advice to the UK Government [2].
This short introduction fails to touch on many of the key achievements of Lord Walton, many of which are outlined in his autobiography, The Spice of Life [3]. Charting his life events from his early years in Durham County through to his ennoblement in the House of Lords in 1989, this can only be considered the first volume of his memoires, because he has remained so proactive since that time. His razor sharp inquiring mind has ensured that his medical and scientific knowledge is always up to date, enabling an informed contribution to the national debate, and, as I am witness, to some tricky questioning at international scientific meetings. But despite his very active international profile, his heart has remained in the north east of England, where he returned from ‘there and back again’ in 2002 – only this time to a restored piggery at Belford in 2002 close to the North Sea coast. Passing the family home on to one of his children, he now lives just down the road. This is a short drive from Berwick railway station, enabling weekly trips via the east coast main line to the House of Lords where he remains actively engaged to this day [2].
As Director of the Institute of Genetic Medicine at Newcastle University and as a clinical neurologist who has worked in the neuromuscular field for 20 years, I am honoured to provide this brief overview. I am in no doubt that naming the Newcastle Neuromuscular Centre after John Walton will serve as an inspiration for current and future researchers to continue along his path, and improve the lives of patients and families affected by neuromuscular disease.