Synthesis,characterization and evaluation of in vitro antimicrobial activity of tri-n-butyltin(IV) complexes of para -azo-carboxylates derived from substituted anilines and 2,4-DNP

Abstract

Tri-n-butyltin(IV) complexes of 4-{(E)-4-hydroxy-3-[(E)-(aryl)iminomethyl] phenyl diazenyl} -benzoic acids (L^1 - 4HH′) and 4-((E)-(3-((E)-(2,4-dinitrophenyl) hydrazono) methyl)-4-hydroxy-phenyl) diazenyl) benzoic acid (L⁵HH′) have been synthesized by reacting 4-[(E)-2-(3-formyl-4-hydroxy-phenyl)-1-diazenyl] benzoic acid (LHH′) with bis-tri-n-butyltin(IV) oxide in anhydrous toluene, and then condensed with appropriate substituted anilines and 2,4-DNP (2,4-dinitro phenyl hydrazine) in ethanol. The complexes 1–5, have been characterized by UV, IR, ¹H-, ¹³C-, ¹¹⁹Sn-NMR spectroscopy in combination with elemental analysis. The elemental analysis and spectroscopic studies of the complexes are consistent with the constitution of the expected products and suggested tetrahedral geometries in solution. The in vitro antimicrobial activities of the compounds were evaluated against various microbes and compared with standard drugs. The compounds were found to possess effective antimicrobial activity against the screened microbes.