Abstract
Acetylcholinesterase (AChE) reactivators are crucial antidotes for the treatment of organophosphate (OP) intoxication. Since pralidoxime, there is still no AChE reactivator able to counteract the full spectrum of different organophosphorus compounds. Our effort has been concerned on development of novel AChE reactivators against tabun and OP pesticides. Hundreds of novel AChE reactivators were prepared. Several novel compounds were found to be potent reactivators both in vitro and in vivo. One compound (K203) was highlighted against tabun poisoning and one compound (K027) was highlighted against OP pesticide poisoning. Selected compounds are becoming promising candidates for replacement of former clinically used AChE reactivators.