Comparing neurodevelopmental outcomes at 30 months by presence of hydrocephalus and shunt status among children enrolled in the MOMS trial

Abstract

PURPOSE:

To evaluate for differences in neurodevelopmental outcomes at 30 months of age for children enrolled in the Management of Myelomeningocele Study (MOMS) based on the presence of hydrocephalus and cerebral shunts.

METHODS:

Children with no hydrocephalus ( $N=$ 27), children with shunted hydrocephalus ( $N=$ 108), and children with unshunted hydrocephalus ( $N=$ 36) were compared at 30 months of age on the Bayley II Mental and Psychomotor Indices, the Peabody Developmental Motor Scales-2 and the Preschool Language Scale, 4 ${}^{\text{th}}$ edition. Generalized linear models were used to adjust for factors significantly different between the groups at baseline. Additional analyses were conducted to evaluate the impact of the severity of hydrocephalus.

RESULTS:

In unadjusted comparisons, statistically significant differences were noted between the three groups on the Peabody Gross Motor Quotient and thus the Total Motor Quotient. After adjustment, no statistically significant differences were identified. In subanalyses, children with more severe hydrocephalus fared worse on the Peabody Fine Motor Quotient (median 88 versus 94, $p=$ 0.005), the Total Motor Quotient (median 70 versus 73, $p=$ 0.02) and both Preschool Language Scale subtests (auditory comprehension: median 93 versus 104, $p=$ 0.02 and expressive communication: median 95 versus 104.5, $p=$ 0.01) and thus the total score (median 92 versus 105, $p=$ 0.004). These results remained significant in the multivariable adjusted model.

CONCLUSION:

No neurodevelopmental differences were noted with children enrolled in MOMS across the three hydrocephalus/shunt groups, although severity of hydrocephalus was associated with poorer outcomes.

Keywords

Hydrocephalus ventriculoperitoneal shunt myelomeningocele neurodevelopmental

1. Introduction

Myelomeningocele, the most common and severe variant of spina bifida, is a complex neural tube defect that occurs in approximately 1 in 1,500 births in the United States [1]. Myelomeningocele is primarily characterized by defective closure of the caudal neural tube during embryonic development, leading to a defect of the bony spine and protrusion of the meninges, spinal cord (depending on the lesion level), and spinal nerves [2]. Individuals with myelomeningocele can experience lower extremity motor and sensory dysfunction and neurogenic bowel and bladder, in addition to a host of long-term neurodevelopmental sequelae resulting from multiple brain abnormalities. These abnormalities may include a concomitant Chiari II malformation, characterized by varying degrees of hindbrain herniation and myelomeningocele-associated hydrocephalus [3, 4]. Hydrocephalus causes axonal damage and decreased cerebral perfusion pressures and is linked to delayed myelination, endocrine derangements, and a constellation of deficits in cognitive, sensory, and motor functions [5, 6, 7]. The impact of hydrocephalus is highly variable in terms of anatomic and functional consequences [8].

Historically, myelomeningocele was and is treated with surgical repair of the defect shortly after birth. Placement of a cerebrospinal fluid (CSF) shunt for hydrocephalus, if present, often occurred within the first few days of life [9, 10]. Current evidence suggests that some of the downstream sequelae of myelomeningocele can be reduced with fetal repair [11]. Theoretical benefits of prenatal repair include reduced exposure of the spinal cord to amniotic fluid and trauma during gestation and delivery and improved cerebrospinal fluid dynamics thereby reducing the degree of hindbrain herniation and hydrocephalus [3, 5, 12]. Advances in fetal surgery in the late 1990s and early 2000s were followed by the Management of Myelomeningocele Study (MOMS). Initial results published in 2011 and updated in 2015 demonstrated that patients undergoing prenatal repair fared significantly better than those undergoing standard postnatal repair as evidenced by reduced severity of hindbrain herniation, reduced rates of hydrocephalus, and improved motor outcomes [13, 14].

While shunting is a well-established treatment modality for hydrocephalus, variability exists regarding which patients receive shunts and when [15, 16, 17, 18]. An estimated 50% of shunts placed in the pediatric population fail within 2 years due to complications including malfunction and infection [16, 17, 19, 20, 21, 22]. These complications require hospitalizations and shunt revisions, posing a burden to patients, their families, and the healthcare system [15, 18, 23, 24, 25, 26]. Studies have suggested that shunt placement in patients with myelomeningocele is associated with a decrease in IQ and an increase in mortality compared to patients who were not shunted [27, 28, 29]. Whether this is due to shunting and its complications or due to the underlying severity of hydrocephalus is controversial [30, 31]. Thus, many neurosurgeons are hesitant to place shunts unless deemed absolutely necessary [9, 12, 15, 16, 17, 19, 20, 32, 33, 34, 35, 36]. Several centers have proposed stringent shunt criteria (based on signs of increased intracranial pressure, severe ventriculomegaly, presence of syringomyelia, pseudomyelomeningocele, or leakage of CSF from the repair site, etc.) in an effort to reduce rates of shunt placement [11, 15, 32, 33, 37]. These criteria have not been well studied or widely accepted. To date, there are no adequate clinical prediction rules to determine patient populations in which the benefits of shunt placement outweigh the risks. The decision to shunt or not is often based on individual experience and preference [15, 18].

In MOMS, hydrocephalus shunt criteria based on expert consensus were pre-established to decrease the influence of biases among treating neurosurgeons. Of MOMS participants who had their shunt criteria evaluated at one year of age, 71.9% of the infants in the prenatal surgery group and 97.8% of the infants in the postnatal surgery group met shunt criteria [14]. Actual rates of shunt placement in prenatal and postnatal repair groups were 44.9% and 83.7%, respectively [13]. Why treating neurosurgeons and families opted not to pursue shunt placement in the face of hydrocephalus is unknown, and may include selection bias as surgeons and families may have had a vested interest in not shunting infants who had previous prenatal repair. In addition, it may relate to hesitancy on the part of neurosurgeons to place shunts even if the predetermined hydrocephalus criteria were met because they use different criteria in their clinical practices.

The analyses presented herein utilize the differing shunting patterns of the MOMS children to evaluate neurodevelopmental outcomes at 30 months by the presence of both hydrocephalus (based on the predetermined criteria) and shunts. Three groups of children are evaluated: children with hydrocephalus and shunts (the shunted hydrocephalus group), children with hydrocephalus but without shunts (the unshunted hydrocephalus group), and children without hydrocephalus and without shunts (the no hydrocephalus group). There were two a priori hypotheses. First, that unshunted hydrocephalus would be associated with worse outcomes on the neurodevelopmental battery at 30 months compared to shunted hydrocephalus and no hydrocephalus. Second, that the no hydrocephalus group would have better neurodevelopmental outcomes than both the hydrocephalus groups (shunted and unshunted).

Table 1
MOMS criteria for the presence of hydrocephalus indicating need for shunt [13]

Criterion 1	At least 2 of the following: An increase in the greatest occipital-frontal circumference adjusted for gestational age defined as crossing percentiles (if a plateau was reached this did not qualify); Bulging fontanelle or split sutures or sunsetting sign; Increasing hydrocephalus on consecutive imaging studies determined by increase in ratio of biventricular diameter to biparietal diameter according to the method of O’Hayon et al. [50]. or; Head circumference $>$ 95 percentile for gestational age
Criterion 2	Presence of marked syringomyelia with ventriculomegaly
Criterion 3	Ventriculomegaly with symptoms of Chiari malformation (stridor, swallowing difficulties, apnea, bradycardia)
Criterion 4	Persistent CSF leakage from the myelomeningocele wound or bulging at the repair site

2. Methods

The MOMS trial was conducted between 2003 and 2010 at three clinical sites with extensive expertise in maternal-fetal surgery (Children’s Hospital of Philadelphia, University of California San Francisco and Vanderbilt University) with George Washington University serving as the Data Coordinating Center and the Eunice Kennedy Shriver National Institute of Child Health and Human Development serving as the sponsor. Institutional Review Board approval was obtained at all sites. While the MOMS trial was enrolling participants, all other maternal-fetal surgery centers ceased performing fetal surgery for spina bifida. During enrollment, 183 maternal-fetal dyads from across the country were randomized to either standard postnatal repair or prenatal repair [14]. The inclusion criteria included fetal myelomeningocele with an upper boundary between T1-S1 with a normal karyotype in a singleton pregnancy between 19.0–25.9 weeks gestation, along with evidence of hindbrain herniation, in a mother at least 18 years of age with residency in the United States. The major exclusion criteria included maternal body mass index of 35 or higher, surgical contraindications such as prior hysterotomy, high risk of preterm birth, placental abruption, major fetal anomalies not associated with spina bifida, and severe fetal kyphosis. After randomization, mothers randomized to the prenatal repair group stayed near the study center for the duration of their pregnancy, while mothers in the standard postnatal repair group went home and returned for planned cesarean delivery and post-natal repair at the study center [14]. After delivery (and repair if in the postnatal group) families returned home for their ongoing care. The first primary outcome of the MOMS trial was a composite measure of fetal/neonatal death plus need for a cerebrospinal fluid shunt based on predetermined hydrocephalus criteria (see Table 1) [13] by 12 months of age [14]. The second primary outcome, at 30 months, was a composite of the Mental Development Index of the Bayley Scales of Infant Development II and motor function adjusted for lesion level [14]. The trial was stopped for efficacy based on the results of both primary outcomes in December of 2010 prior to the planned enrollment of 200 maternal-fetal dyads [14].

Figure 1.

Participants by hydrocephalus and shunt status.

Of those 183 participants (91 in the prenatal surgery group and 92 in the postnatal surgery group), there were six deaths and two additional children who were not assessed at 30 months. See Fig. 1 for a flow chart of the participants. At the 30-month visit, 175 children were assessed for neurodevelopmental outcomes. Hydrocephalus criteria (Table 1) and shunt status were assessed by one year of age. Of those with neurodevelopmental evaluations, 106 met criteria for hydrocephalus and had a shunt placed. Two more children had third ventriculostomies, totaling 108 children with shunted hydrocephalus. Of the remaining 67 children, 36 met criteria but did not have shunts placed (unshunted hydrocephalus) and 27 did not meet hydrocephalus criteria and were not shunted (no hydrocephalus) [13]. Four children in the postnatal repair group had shunts placed without meeting hydrocephalus criteria and were excluded from the analysis. Two of these children had shunts placed at the time of the spina bifida repair by their local neurosurgeon. One had a shunt placed within a week of repair and one had a shunt placed at the age of four months [13].

Table 2

Characteristics by hydrocephalus and shunting status

All	No hydrocephalus	Shunted hydrocephalus	Unshunted hydrocephalus	$p$ -value
	$N=$ 27	$N=$ 108	$N=$ 36
Maternal education at screening – yrs	14.9 $\pm$ 1.6	15.0 $\pm$ 1.7	15.0 $\pm$ 1.7	0.87
Prenatal repair group	25 (92.6)	39 (36.1)	23 (63.9)	$<$ 0.001
Female child	10 (37.0)	59 (54.6)	23 (63.9)	0.10
Lesion level at L3 or lower	21 (77.8)	84 (77.7)	26 (72.2)	0.78
Gestational age at delivery – wks	34.9 $\pm$ 2.8	36.1 $\pm$ 2.4	35.2 $\pm$ 2.8	0.003
Ventricle size at screening* – mm	8.5 $\pm$ 2.3	11.8 $\pm$ 4.1	10.9 $\pm$ 2.5	$<$ 0.001

Data presented as mean $\pm$ SD or $n$ (%). Screening using fetal MRI occurred prior to randomization in MOMS.

In this analysis of MOMS data, neurodevelopmental assessment results were used to evaluate differences in outcomes for the three hydrocephalus criteria/shunt groups of subjects: Bayley II Mental and Psychomotor Development Indices, the Peabody Developmental Motor Scale-2 and the Preschool Language Scale 4 ${}^{\text{th}}$ ed. The Bayley Scales of Infant Development-II were widely used to screen for developmental delay among infants 1–42 months of age [38, 39]. The Bayley Mental Development Index evaluates several types of abilities including sensory/perceptual acuities, discrimination and response, acquisition of object constancy, memory learning, and problem solving. Also evaluated are vocalization and beginning of verbal communication, basis of abstract thinking, habituation, mental mapping, complex language, and mathematical concept formation. The Bayley Psychomotor Development Index assesses the degree of body control, fine/gross motor skills, dynamic movement, postural imitation, and the ability to recognize objects by sense of touch. The standardized scores by age on both the Mental Developmental Index and the Psychomotor Developmental Index have means of 100 with standard deviations of 15. Both Bayley Development Indices are validated measures that have high correlation coefficients for test and retest reliability [38]. Knowing that children with spina bifida tend to score poorly on the Psychomotor Development Index [40, 41, 42]. and that scores below 50 are not standardizable, the measure was dichotomized using a cutoff of 50. The Mental Development Index score was evaluated on a standard continuous scale based on age. The Peabody Developmental Motor Scale-2 is similarly validated and reliable and evaluates stationary control, locomotion, object manipulation, grasping, and visual-motor integration [39]. The grasping and visual motor subscales are combined to create the Fine Motor Quotient and the stationary, locomotion and object manipulation comprise the Gross Motor Quotient. The sum of these two quotients yields the Total Motor Quotient. Scores of 90–110 are considered average. The Preschool-Language Scale is a standardized, validated tool used to assess expressive and receptive language [43]. Standardized subscores which are normalized at 100 by age are reported for auditory comprehension (receptive language) and expressive communication which includes preverbal behaviors, linguistic skills and pre-literacy skills, as well as a total language score [43].

In univariable analysis, continuous variables were compared using the Wilcoxon test; categorical variables were compared with the chi-square or Fisher’s exact test as appropriate. Normal order score transformations were employed for each of the outcomes as many of the scores from the evaluations are not normally distributed in this population. Kruskal-Wallis tests were used to determine differences between the three hydrocephalus criteria/shunt groups in these scores. Generalized linear models were used in a multivariable analysis adjusted for pre or postnatal repair group, maternal education and ventricular size at screening. Gestational age at birth was not included because it was highly correlated with prenatal repair status. To determine how the severity of hydrocephalus is associated with the outcomes, the same methods were employed for only the children who met hydrocephalus criteria. Those who met only one criterion were compared to those who met two or more hydrocephalus criteria. The multivariable model included adjustment for surgery group assignment, maternal education, and ventricular size at screening.

Table 3

Outcomes by hydrocephalus and shunt status

All	No hydrocephalus			Shunted hydrocephalus			Unshunted hydrocephalus			$p$ -value*
	$n$ (%)			$n$ (%)			$n$ (%)
Bayley Psychomotor Index $\geqslant$ 50	15 (55.6)			41 (38.0)			15 (41.7)			0.25
	$N$	Median	IQR ${}^{\text{\#}}$	$N$	Median	IQR ${}^{\text{\#}}$	$N$	Median	IQR ${}^{\text{\#}}$	$p$ -value**
Bayley Mental Index	27	91.0	(13.0)	108	91.5	(20.5)	36	94.0	(9.0)	0.43
Peabody Developmental Motor Scale
Fine motor quotient	27	97.0	(18.0)	107	94.0	(12.0)	36	94.0	(15.0)	0.15
Gross motor quotient	27	72.0	(22.0)	107	61.0	(9.0)	36	64.0	(13.0)	0.04
Total motor quotient	27	78.0	(18.0)	107	71.0	(9.0)	36	74.5	(11.5)	0.03
Preschool Language Scale:
Auditory comprehension	27	102.0	(26.0)	99	102.0	(25.0)	36	103.0	(20.0)	0.88
Expressive communication	26	102.0	(17.0)	104	102.0	(23.0)	36	106.0	(13.5)	0.83
Total language score	26	105.0	(27.0)	99	100.0	(24.0)	36	106.0	(18.0)	0.91

For all scores, higher indicates better score. ${}^{\text{\#}}$ Interquartile range. * $p$ -value from Chi-square test. ** $p$ -values from Kruskal-Wallis comparison.

Table 4

Adjusted models for neurodevelopmental outcomes comparing unshunted hydrocephalus to no hydrocephalus and shunted hydrocephalus to no hydrocephalus

All	Odds ratio	95% confidence interval	$p$ -value*
Bayley Psychomotor Index $\geqslant$ 50
Unshunted hydrocephalus vs. no hydrocephalus	0.70	(0.24–2.10)	0.53
Shunted hydrocephalus vs. no hydrocephalus	0.74	(0.25–2.12)	0.57
	$\beta$ estimate	95% confidence interval	$p$ -value**
Bayley Mental Index
Unshunted hydrocephalus vs. no hydrocephalus	0.28	( $-$ 0.23–0.80)	0.28
Shunted hydrocephalus vs. no hydrocephalus	0.10	( $-$ 0.40–0.60)	0.70
Peabody Developmental Gross Motor Scale:
Fine motor quotient
Unshunted hydrocephalus vs. no hydrocephalus	0.11	( $-$ 0.40–0.63)	0.66
Shunted hydrocephalus vs. no hydrocephalus	$-$ 0.23	( $-$ 0.73–0.27)	0.38
Gross motor quotient
Unshunted hydrocephalus vs. no hydrocephalus	0.02	( $-$ 0.47–0.51)	0.94
Shunted hydrocephalus vs. no hydrocephalus	0.02	( $-$ 0.45–0.50)	0.92
Total motor quotient
Unshunted hydrocephalus vs. no hydrocephalus	0.003	( $-$ 0.50–0.51)	0.99
Shunted hydrocephalus vs. no hydrocephalus	$-$ 0.11	( $-$ 0.60–0.38)	0.65
Preschool Language Scale:
Auditory comprehension score
Unshunted hydrocephalus vs. no hydrocephalus	0.06	( $-$ 0.45–0.58)	0.82
Shunted hydrocephalus vs. no hydrocephalus	0.08	( $-$ 0.42–0.58)	0.74
Expressive communication score
Unshunted hydrocephalus vs. no hydrocephalus	0.11	( $-$ 0.40–0.64)	0.68
Shunted hydrocephalus vs. no hydrocephalus	0.03	( $-$ 0.49–0.54)	0.92
Total language score
Unshunted hydrocephalus vs. no hydrocephalus	0.11	( $-$ 0.41–0.63)	0.68
Shunted hydrocephalus vs. no hydrocephalus	0.08	( $-$ 0.43–0.60)	0.75

Adjusted for: surgery assignment (prenatal vs postnatal), ventricular size at screening and maternal education.

Table 5

Severity of hydrocephalus in those who met criteria for shunting

	Univariable							Adjusted
	1 criterion met			2 $+$ criteria met
		$n$	%		$n$	%	$p$ -value*	OR	95% CI	$p$ -value*
Bayley Psychomotor Index $\geqslant$ 50		49	(42)		7	(26)	0.13	0.56	(0.21–1.50)	0.25
	$N$	Median	IQR ${}^{\text{\#}}$	$N$	Median	IQR ${}^{\text{\#}}$	$p$ -value**	Estimate	95% CI	$p$ -value**
Bayley Mental Index	117	94.0	(15.0)	27	83.0	(20.0)	0.09	$-$ 0.28	( $-$ 0.71–0.15)	0.20
Peabody Developmental Motor Scale:
Fine motor quotient	117	94.0	(12.0)	26	88.0	(12.0)	0.005	$-$ 0.61	( $-$ 1.01– $-$ 0.21)	0.003
Gross motor quotient	117	61.0	(13.0)	26	61.0	(9.0)	0.44	$-$ 0.14	( $-$ 0.54–0.25)	0.47
Total motor quotient	117	73.0	(11.0)	26	70.0	(7.0)	0.02	$-$ 0.47	( $-$ 0.87– $-$ 0.72)	0.02
Preschool Language Scale:
Auditory comprehension	113	104.0	(25.0)	22	93.0	(17.0)	0.02	$-$ 0.44	( $-$ 0.89–0.001)	0.05
Expressive communication	114	104.5	(20.0)	26	95.0	(16.0)	0.01	$-$ 0.48	( $-$ 0.92– $-$ 0.05)	0.03
Total language score	113	105.0	(22.0)	22	92.0	(17.0)	0.004	$-$ 0.54	( $-$ 0.99– $-$ 0.08)	0.02

* $p$ -value from Chi-square comparison. ** $p$ -values from Wilcoxon comparison. Adjusted for: assigned surgery group, ventricular size at screening and maternal education.

3. Results

The characteristics of the three groups of subjects are provided in Table 2. There were no statistically significant differences in maternal education, fetal gender, or lesion level. As demonstrated previously [13], children in the prenatal group less frequently met shunting criteria and were less frequently shunted. Children in the prenatal group represented 92.6% of the children who did not meet shunt criteria, 63.9% of the children who met shunt criteria but who were not shunted, and 36.1% of the children who met criteria and were shunted ( $p<$ 0.001). Gestational age at delivery differed by group. Children in the no hydrocephalus group were on average delivered at 34.9 weeks gestation compared to 36.1 weeks for children with shunted hydrocephalus and 35.2 weeks for children with unshunted hydrocephalus ( $p=$ 0.003). Average ventricular size at prenatal screening was also statistically different between the three groups with the no hydrocephalus group having an average ventricular size of 8.5 mm at prenatal screening, compared to 11.8 mm for the shunted hydrocephalus group and 10.9 mm for the unshunted hydrocephalus group ( $p<$ 0.001). Children with shunted hydrocephalus more commonly met two or more shunting criteria compared to children with unshunted hydrocephalus who more commonly only met one shunting criteria ( $p=$ 0.005).

Among the 108 children with shunted hydrocephalus, 91.7% met the first hydrocephalus criteria (at least 2 of the following: crossing head circumference percentiles; bulging fontanelle or split sutures or sunsetting sign; increased hydrocephalus on consecutive imaging as determined by the ratio of biventricular diameter to biparietal diameter; or head circumference greater than 95 percentile for gestational age), 5.6% met criteria 2 (presence of marked syringomyelia with ventriculomegaly), 10.2% met criteria 3 (ventriculomegaly with symptoms of Chiari malformation) and 19.4% met criteria 4 (persistent CSF leak or bulging from the repair site). The sum is more than 100% because some children met more than one criteria. In contrast, among the 36 children with unshunted hydrocephalus, 100% met the first criteria, 2.8% met the fourth criteria, while none met criterion 2 or 3.

Table 3 includes univariable comparisons between the 3 groups (no hydrocephalus, shunted hydrocephalus and unshunted hydrocephalus) for the neurodevelopmental outcomes. There were no significant differences between these groups for either of the Bayley Indices (Mental or Psychomotor) or for the Preschool Language Scale (Auditory Comprehension, Expressive Communication or Total Language score). The Peabody Gross Motor Quotient (comprised of the stationary, locomotion and object manipulation subscales) was significantly different between the hydrocephalus/shunt groups ( $p=$ 0.04), as was the Total Motor Quotient ( $p=$ 0.03) due to the differences in the aforementioned Gross Motor Quotient. All three groups of children scored in the abnormal range on the Bayley Psychomotor Index and the Peabody Gross Motor Quotient (and thus the Total Motor Quotient). In the multivariable regression analysis, shown in Table 4, adjusting for assigned surgery group (prenatal or postnatal), ventricular size at screening, and maternal education, the hydrocephalus/shunt groups did not differ for any of the neurodevelopmental outcomes.

In order to assess the association of the severity of hydrocephalus and the outcomes for all children who met criteria for hydrocephalus, comparisons were made between those who met one criterion and those who met two or more criteria. Table 5 shows the univariate analysis which shows no differences in those who met one versus more than one criteria for the Bayley Mental or Psychomotor Indices. However, there was a difference by severity for the Peabody Fine Motor Quotient ( $p=$ 0.005) and hence in the Total Motor Quotient ( $p=$ 0.02), such that children with more severe hydrocephalus scored worse. Additionally, for the Preschool Language Scale, both subscales (Auditory Comprehension and Expressive Communication) were different between those who met one criterion and those who met more than one criteria ( $p=$ 0.02 and $p=$ 0.01, respectively) which lead to the Total Language Score difference ( $p=$ 0.004) as well. These differences hold true in the multivariate analysis adjusting for the covariates: assigned surgery group, ventricular size at screening, and maternal education as shown in Table 5.

4. Discussion

Neurodevelopmental outcomes at 30 months of age were analyzed for 171 children participating in the MOMS trial. Children were categorized into three groups based on the presence of hydrocephalus and shunt placement to determine if the neurodevelopmental outcomes differed. In univariable analysis, differences were found on the Peabody Developmental Gross Motor and Total Motor Quotients. After adjustment, none of the comparisons were statistically different between the three groups. Children with unshunted hydrocephalus did not fare worse from a neurodevelopmental perspective as was expected. Additional analysis of only the children with hydrocephalus demonstrated that severity of the hydrocephalus, as measured by the number of hydrocephalus criteria met, was associated with poorer neurodevelopmental functioning. Children with more severe hydrocephalus had lower scores on the Fine Motor Quotient, and thus the Total Motor Quotient of the Peabody Developmental Motor Scale, and both the Auditory Comprehension and Expressive Communication sections of the Preschool School Language Scale and thus the Total Language Score.

This is the first study to evaluate neurodevelopmental outcomes for children shunted or unshunted with documented hydrocephalus based on predetermined clinical criteria compared to children without hydrocephalus. The results demonstrate relatively similar neurodevelopmental profiles between the three groups -no hydrocephalus, shunted hydrocephalus, and unshunted hydrocephalus. In contrast, other studies have found that children with spina bifida without hydrocephalus fare better than those with hydrocephalus, although different outcome measures were used [40, 42, 44, 45, 46]. We also note that in our unadjusted analysis, children without hydrocephalus seemed to fare better neurodevelopmentally for some motor outcomes. However, this difference did not persist after adjustment. This may be in part because ventricular size at screening differed statistically between the 3 groups indicating the need to control for this variable in our adjusted analysis. This difference was found to be predictive of scores on the Bayley Psychomotor Index [47]. In our analyses, children with more severe hydrocephalus fared worse on some neurodevelopmental tests likely indicating that severity is a more important driver of outcomes than whether or not a shunt was placed. Importantly, in this cohort, children with more severe hydrocephalus were more likely to have a shunt placed. This indicates the need for further research using groups of children with and without shunts who have the same severity of hydrocephalus to determine if shunting itself has an impact on neurodevelopmental outcomes.

One goal of evaluating neurodevelopmental outcomes by hydrocephalus and shunt status was to provide information that may eventually be incorporated into a clinical decision-making tool for the management of hydrocephalus in children with spina bifida. If, for example, children who met hydrocephalus criteria but were not shunted fared worse than children who met criteria and were shunted, this would indicate that not placing a shunt for a child with hydrocephalus might have long-term deleterious consequences. Or conversely, if children with shunted hydrocephalus fared worse than those with unshunted hydrocephalus, permitting some amount of ventriculomegaly instead of proceeding with a shunt would potentially be warranted. The lack of difference between these groups of children in this study does support the idea that some permissible hydrocephalus is likely a reasonable option. This is important as many neurosurgeons are actively trying to reduce shunting rates [48]. Additional research is necessary before this conclusion can be made with confidence. Furthermore, it is important to remember that in this cohort, children with more severe hydrocephalus fared worse on some outcomes and that these same children were shunted more frequently. This highlights the impact of severe hydrocephalus on neurodevelopmental outcomes.

This study has several limitations. First, number of shunt revisions which have been demonstrated to negatively impact cognitive outcomes [8], were not taken into account. Second, the timing in infancy at which the children met hydrocephalus criteria was not assessed in this analysis, which may be important because the long-term impacts of hydrocephalus may differ with age of onset. Third, although the number of study criteria for hydrocephalus that are met is known in this study, this is not a standard measure of severity. How this correlates to other measures of hydrocephalus severity is not known. Fourth, the outcomes analyzed are quite proximal and may not correlate to later childhood outcomes. Fifth, morphologic brain differences were not noted in MOMS and therefore were not included in this analysis although they could be considered in future studies [49]. Sixth, a majority of the sample had hydrocephalus and were shunted making the comparison groups unequal. The power to detect differences would have been increased with larger comparison groups. Lastly, mothers enrolled in MOMS may not be similar to other mothers with children with spina bifida, limiting the generalizability of the findings.

5. Conclusions

This analysis of 171 children enrolled in the MOMS trial evaluated neurodevelopmental outcomes at 30 months by hydrocephalus and shunt status. After controlling for multiple factors, there were no statistical differences in the outcomes when comparing children without hydrocephalus, children with shunted hydrocephalus and children with unshunted hydrocephalus. Children with more severe hydrocephalus fared worse on some neurdevelopmental assessments. Further research is warranted to evaluate neurodevelopmental outcomes by hydrocephalus severity and shunt status to help develop decision-making tools to aid neurosurgeons in the management of hydrocephalus in patients with spina bifida.

Footnotes

Acknowledgments

The authors are funded by the NIH NICHD U01HD0 68541 MOMS2: Follow up of the Mangement of Myelomeningocele Study. Thom and Burrows were also funded by U01-HD041665 MOMS: Management of Myelomeningocele Study.

Conflict of interest

The authors have no other financial disclosures and no conflicts of interest.

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Comparing neurodevelopmental outcomes at 30 months by presence of hydrocephalus and shunt status among children enrolled in the MOMS trial

Abstract

PURPOSE:

METHODS:

RESULTS:

CONCLUSION:

Keywords

1. Introduction

Table 1 MOMS criteria for the presence of hydrocephalus indicating need for shunt [13]

4. Discussion

5. Conclusions

Footnotes

Acknowledgments

Conflict of interest

References

Table 1
MOMS criteria for the presence of hydrocephalus indicating need for shunt [13]